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首页> 外文期刊>Biochemistry >Unique Bipolar Gene Architecture in the RNA Genome of Influenza A Virus
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Unique Bipolar Gene Architecture in the RNA Genome of Influenza A Virus

机译：流感RNA基因组的独特双极基因建筑

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摘要

The genome of influenza A virus consists of eight single-stranded negative-polarity RNA segments. The eighth segment (NS) encodes the anti-interferon protein NS1 (27 kDa) and the nuclear export protein NEP (14 kDa) via the classic negative-sense strategy. It also contains an additional positive-sense open reading frame that can be directly translated into the negative strand protein 8 (NSP8; 18-25 kDa in different strains). The existence of three or more genes of the opposite polarity in the same locus of a single-stranded RNA appears to be a unique ("economical") type of gene architecture in living organisms. In silico analysis of genomes of human and animal influenza A viruses revealed that the NSP8 gene had emerged in the influenza A virus population about 100 years ago ("young" gene) and is highly evolutionary variable. The obtained experimental data suggest that NSP8 gene is expressed in the infected animals, which strengthens the concept of bipolar (ambisense) strategy of the influenza A virus genome. The high variability of the NSP8 protein suggests that the "young" NSP8 gene is in the process of functional optimization. Further accumulation of mutations may alter the functions of mature NSP8 protein and lead to the emergence of mature bipolar influenza A virus with unexpected properties that would be threatening for humans and animals.
机译：流感病毒的基因组由八个单链阴性RNA段组成。第八段（NS）通过经典的负面感应策略编码抗干扰素蛋白NS1（27kDA）和核出口蛋白NEP（14kDA）。它还含有另外的正义开放阅读框，可直接翻译成负链蛋白8（NSP8; 18-25kDa在不同菌株中）。在单链RNA的相同基因座中存在三个或更多个相反极性的基因似乎是生物体中的独特（“经济性”）基因架构。在硅和动物流感的基因组分析中，病毒揭示了NP8基因在大​​约100年前的流感病毒人群中出现（“年轻”基因）并且是高度进化的变量。所获得的实验数据表明NSP8基因在受感染的动物中表达，这加强了流感病毒基因组的双极（舒大）策略的概念。 NSP8蛋白的高可变性表明“年轻”NSP8基因在功能优化过程中。突变的进一步积累可能改变成熟NP8蛋白的功能，并导致成熟双极流感的出现具有意外的性质，这些病毒将威胁人类和动物。

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