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New Data on Programmed Risks of Death in Normal Mice and Mutants with Growth Delay

机译：关于正常小鼠和生长延迟的突变体中死亡风险的新数据

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摘要

Study of the lifespans of normal (non mutant) mice and growth delay mutants has shown that mortality rates for both kinds of animals exhibit reproducible fluctuations. In the case of the mutant mice, the positions of peaks on the differential mortality curves (mortality rate plotted against lifespan) coincided in different-sex groups of animals and in same-sex subgroups of animals. Differential mortality curves of the mutant mice also had a peak at 1 month of age that was absent from the differential mortality curves of the normal mice. In the case of normal animals, positions of most peaks were the same in the studied independent subgroups of males, and to a lesser extent - independent subgroups of females, which might be explained by a shift in mortality peak positions due to the reproductive activity of females. Similar positions of mortality rate peaks in the differential mortality curves for animals from independent groups and subgroups indicate the existence of increased risks of death at specific ages. The observed pattern could be due to the programming in the genome of both the periods of increased risk of death and the intermitting intervals of stable development.
机译：对正常（非突变体）小鼠和生长延迟突变体的寿命的研究表明，两种动物的死亡率表现出可重复的波动。在突变小鼠的情况下，峰值对差异死亡率曲线的峰值（绘制反对寿命的死亡率率）在动物的不同性别组和动物的同性亚组中吻合。突变小鼠的差异死亡率曲线在普通小鼠的差异死亡率曲线中，1个月的1个月也具有峰。在正常动物的情况下，在研究的独立的男性的独立亚组中，大多数峰的位置是相同的，并且对女性的较小程度的亚组，这可能通过由于生殖活性而通过死亡率峰值位置的转变来解释女性。来自独立组和亚组的动物的差异死亡率曲线中死亡率峰值的类似位置表明，在特定年龄的情况下，存在增加死亡风险。观察到的模式可能是由于在增加死亡风险和稳定发展的间隔的过程中的基因组中的编程。

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