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首页> 外文期刊>Biological & pharmaceutical bulletin >Preparation of Curcumin-Containing alpha-,beta-, and gamma-Cyclodextrin/Polyethyleneglycol-Conjugated Gold Multifunctional Nanoparticles and Their in Vitro Cytotoxic Effects on A549 Cells
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Preparation of Curcumin-Containing alpha-,beta-, and gamma-Cyclodextrin/Polyethyleneglycol-Conjugated Gold Multifunctional Nanoparticles and Their in Vitro Cytotoxic Effects on A549 Cells

机译：制备含姜黄素的α，β-和γ-环糊精/聚乙二醇 - 缀合的金多功能纳米颗粒及其对A549细胞的体外细胞毒性作用

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摘要

Gold nanoparticles (GNPs) have promising properties such as photothermal effects and could be useful for imaging and as multifunctional nanocarriers for various drugs. In this study, we synthesized polyethyleneglycol (PEG)-grafted GNPs and conjugated them with cyclodextrin (CD) to incorporate curcumin. Curcumin has anticancer effects but its therapeutic application is limited due to poor water solubility. Three types of CDs (alpha-, beta-, and gamma-CDs) were conjugated with PEGylated GNPs and the curcumin-containing CD/PEG-conjugated GNPs (cur-CD-GNPs) were characterized. Transmission electron microscopy and dynamic light scattering results showed that these cur-CD-GNPs have a small gold nanocore (approximately 5 nm) and the average size of the three cur-CD-GNPs was approximately 25-35 nm. Curcumin was efficiently incorporated into the beta-CD solution and the loading efficiency of curcumin in beta-CD-GNPs was the highest of the three types of CD-GNPs prepared. The cytotoxic effect of cur-CD-GNPs was investigated using a human lung cancer cell line. All cur-CD-GNPs exhibited cytotoxic effects comparable to that of curcumin solution and CD-GNPs without curcumin were not cytotoxic. These results suggest that cur-CD-GNPs may be a useful multifunctional nanomedicine, although in vivo investigations are required.
机译：金纳米颗粒（GNP）具有令人欣赏的性质，如光热效应，并且可用于成像和作为各种药物的多功能纳米载体。在该研究中，我们合成聚乙二醇（PEG） - 移植的GNP，并用环糊精（CD）将它们缀合，掺入姜黄素。姜黄素具有抗癌效果，但由于水溶解度差，其治疗申请受到限制。将三种类型的Cd（α，β-和γ-Cds）与聚乙二醇化的GNP缀合，表征含姜黄素的CD / PEG缀合的GNPS（CD-CD-GNPS）。透射电子显微镜和动态光散射结果表明，这些CD-CD-GNP具有小的金纳米（约5nm），三种CD-GNP的平均尺寸约为25-35nm。姜黄素被有效地掺入β-CD溶液中，并且β-CD-GNP中姜黄素的负载效率是制备的三种CD-GNP中的最高类型。使用人肺癌细胞系研究了CD-CD-GNP的细胞毒性效应。所有CD-GNP都表现出与姜黄素溶液的细胞毒性效应相当，没有姜黄素的CD-GNPS不是细胞毒性。这些结果表明，CD-GNPS可以是有用的多功能纳米Medicine，尽管需要体内调查。

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  • 作者

    Hoshikawa Akihiro; Nagira Mizuki; Tane Masafumi; Fukushige Kaori; Tagami Tatsuaki; Ozeki Tetsuya;

  • 作者单位

    Nagoya City Univ Grad Sch Pharmaceut Sci Drug Delivery &

    Nano Pharmaceut Mizuho Ku 3-1 Tanabe Dori Nagoya Aichi 4678603 Japan;

    Nagoya City Univ Grad Sch Pharmaceut Sci Drug Delivery &

    Nano Pharmaceut Mizuho Ku 3-1 Tanabe Dori Nagoya Aichi 4678603 Japan;

    Nagoya City Univ Grad Sch Pharmaceut Sci Drug Delivery &

    Nano Pharmaceut Mizuho Ku 3-1 Tanabe Dori Nagoya Aichi 4678603 Japan;

    Nagoya City Univ Grad Sch Pharmaceut Sci Drug Delivery &

    Nano Pharmaceut Mizuho Ku 3-1 Tanabe Dori Nagoya Aichi 4678603 Japan;

    Nagoya City Univ Grad Sch Pharmaceut Sci Drug Delivery &

    Nano Pharmaceut Mizuho Ku 3-1 Tanabe Dori Nagoya Aichi 4678603 Japan;

    Nagoya City Univ Grad Sch Pharmaceut Sci Drug Delivery &

    Nano Pharmaceut Mizuho Ku 3-1 Tanabe Dori Nagoya Aichi 4678603 Japan;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
  • 关键词

    curcumin; cyclodextrin; gold nanoparticle; nanomedicine; PEGylation; poorly-water-soluble drug;

    机译：姜黄素;环糊精;金纳米粒子;纳米医生;聚乙二醇化;水溶性差;

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