Aha-type co-chaperones: the alpha or the omega of the Hsp90 ATPase cycle?

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Aha-type co-chaperones: the alpha or the omega of the Hsp90 ATPase cycle?

机译：AHA型共伴侣：HSP90 ATPase循环的alpha或Ω

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Heat shock protein 90 (Hsp90) is a dimeric molecular chaperone that plays an essential role in cellular homeostasis. It functions in the context of a structurally dynamic ATP-dependent cycle to promote conformational changes in its clientele to aid stability, maturation, and activation. The client activation cycle is tightly regulated by a cohort of co-chaperone proteins that display specific binding preferences for certain conformations of Hsp90, guiding Hsp90 through its functional ATPase cycle. Aha-type co-chaperones are well-known to robustly stimulate the ATPase activity of Hsp90 but other roles in regulating the functional cycle are being revealed. In this review, we summarize the work done on the Aha-type co-chaperones since the 1990s and highlight recent discoveries with respect to the complexity of Hsp90 cycle regulation.

机译：热休克蛋白90（HSP90）是一种二聚体分子伴侣，其在细胞稳态中起重要作用。它在结构动态的ATP依赖周期的上下文中起作用，以促进其客户的构象变化以辅助稳定性，成熟和激活。客户端激活循环通过群副伴侣蛋白质紧密调节，该族蛋白质显示器通过其功能ATP酶周期显示HSP90的某些构象，引导HSP90。众所周知，AHA型共伴侣均可刺激HSP90的ATP酶活性，但正在揭示调节功能循环的其他作用。在这篇综述中，我们总结了自20世纪90年代以来，从1990年代自20世纪90年代突出了AHA型共伴侣的工作以及关于HSP90周期调节的复杂性的最新发现。

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《Biological chemistry》 |2020年第4期|共12页
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正文语种 eng
中图分类生物化学;
关键词
Aha1; Aha-type; ATPase; ATPase stimulation; co-chaperones; Hsp90;

机译：aha1;aha型;AtPase;Atpase刺激;共伴侣;HSP90;

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专利

1. Aha-type co-chaperones: the alpha or the omega of the Hsp90 ATPase cycle? [J] . Biological chemistry . 2020,第4期

机译：AHA型共伴侣：HSP90 ATPase循环的alpha或Ω
2. The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins. [J] . McLaughlin SH, Sobott F, Yao ZP, Journal of Molecular Biology . 2006,第3期

机译：伴侣蛋白p23阻止了Hsp90 ATPase循环以捕获客户蛋白。
3. The Co-chaperone Sba1 Connects the ATPase Reaction of Hsp90 to the Progression of the Chaperone Cycle. [J] . Richter K, Walter S, Buchner J Journal of Molecular Biology . 2004,第5期

机译：伴侣伴侣Sba1将Hsp90的ATPase反应与伴侣周期的进行联系起来。
4. Hsp90/Cdc37 Chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin A [C] . Abhinav Grover, Ashutosh Shandilya, Vibhuti Agrawal, Asia-Pacific Bioinformatics Conference . 2012

机译：HSP90 / CDC37伴侣/共伴侣复合物，采用草药药物的作用方式阐明了一种新的结抗癌目标A.
5. A tale of two co-chaperones: Identifying the function of the Hsp90 co-chaperones Cpr6 and Cpr7. [D] . Zuehlke, Abbey Dyanne. 2013

机译：两个辅助伴侣的故事：识别Hsp90辅助伴侣Cpr6和Cpr7的功能。
6. The conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation [O] . Rebecca Mercier, Annemarie Wolmarans, Jonathan Schubert, -1

机译：Aha型伴侣蛋白中保守的NxNNWHW基序调节Hsp90 ATPase刺激的动力学
7. Co-chaperone regulation of conformational switching in the Hsp90 ATPase cycle [O] . Siligardi, G, Hu, B, Panaretou, B, 2004

机译：伴侣伴侣在Hsp90 ATPase循环中构象转换的调控

Aha-type co-chaperones: the alpha or the omega of the Hsp90 ATPase cycle?

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