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Structural and mechanistic aspects of S-S bonds in the thioredoxin-like family of proteins

机译：S-S键在硫昔宁的蛋白质系列中的结构和机械方面

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摘要

Disulfide bonds play a critical role in a variety of structural and mechanistic processes associated with proteins inside the cells and in the extracellular environment. The thioredoxin family of proteins like thioredoxin (Trx), glutaredoxin (Grx) and protein disulfide isomerase, are involved in the formation, transfer or isomerization of disulfide bonds through a characteristic thiol-disulfide exchange reaction. Here, we review the structural and mechanistic determinants behind the thiol-disulfide exchange reactions for the different enzyme types within this family, rationalizing the known experimental data in light of the results from computational studies. The analysis sheds new atomic-level insight into the structural and mechanistic variations that characterize the different enzymes in the family, helping to explain the associated functional diversity. Furthermore, we review here a pattern of stabilization/destabilization of the conserved active-site cysteine residues presented beforehand, which is fully consistent with the observed roles played by the thioredoxin family of enzymes.
机译：二硫键在与细胞内和细胞外环境中的蛋白质相关的各种结构和机械过程中起着关键作用。通过特征硫醇二硫化物交换反应，患有硫昔林（Trx），戊烷素（GRX）和蛋白二硫化物异构酶等蛋白蛋白（TRX），戊二醛毒素（GRX）和蛋白二硫化物异构酶。在这里，我们审查了该家族内不同酶类型的硫醇二硫化物交换反应背后的结构和机械决定因素，鉴于计算研究的结果，合理化已知的实验数据。分析揭示了新的原子级洞察，以对家庭中不同酶的结构和机械变化的结构和机械变化，有助于解释相关的功能多样性。此外，我们在此审查了预先呈现的保守的活性位点半胱氨酸残基的稳定性/稳定化模式，这与硫氧菊酯酶的观察到的角色完全一致。

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  • 来源
    《Biological chemistry》 |2019年第5期|共13页
  • 作者

    Sérgio F.Sousa; Rui P.P.Neves; Sodiq O.Waheed; Pedro A.Fernandes; Maria Jo?oRamos;

  • 作者单位

    UCIBIO@REQUIMTE Departamento de Química e Bioquímica Faculdade de Ciências Universidade do Porto;

    UCIBIO@REQUIMTE Departamento de Química e Bioquímica Faculdade de Ciências Universidade do Porto;

    UCIBIO@REQUIMTE Departamento de Química e Bioquímica Faculdade de Ciências Universidade do Porto;

    UCIBIO@REQUIMTE Departamento de Química e Bioquímica Faculdade de Ciências Universidade do Porto;

    UCIBIO@REQUIMTE Departamento de Química e Bioquímica Faculdade de Ciências Universidade do Porto;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物化学;
  • 关键词

    disulfide; Grx; PDI; pKa; thiol-disulfide exchange; Trx;

    机译：二硫化物;GRX;PDI;PKA;硫醇二硫化物交换;TRX;

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