...
首页> 外文期刊>Biological chemistry >The comparative biochemistry of viruses and humans: an evolutionary path towards autoimmunity
【24h】

The comparative biochemistry of viruses and humans: an evolutionary path towards autoimmunity

机译:病毒与人类的比较生物化学 - 一种朝向自身免疫的进化路径

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       

摘要

Analyses of the peptide sharing between five common human viruses (Borna disease virus, influenza A virus, measles virus, mumps virus and rubella virus) and the human proteome highlight a massive viral vs. human peptide overlap that is mathematically unexpected. Evolutionarily, the data underscore a strict relationship between viruses and the origin of eukaryotic cells. Indeed, according to the viral eukaryogenesis hypothesis and in light of the endosymbiotic theory, the first eukaryotic cell (our lineage) originated as a consortium consisting of an archaeal ancestor of the eukaryotic cytoplasm, a bacterial ancestor of the mitochondria and a viral ancestor of the nucleus. From a pathologic point of view, the peptide sequence similarity between viruses and humans may provide a molecular platform for autoimmune crossreactions during immune responses following viral infections/immunizations.
机译:分析五种常见人类病毒(诞生病毒,流感病毒,麻疹病毒,腮腺炎病毒和风疹病毒)的肽共享分析和人类蛋白质组突出了数学上意外的巨大病毒与人肽重叠。 进化地,数据强调了病毒与真核细胞的起源之间的严格关系。 实际上,根据病毒真核的假设和鉴于内骨生物学理论,第一个真核细胞(我们的谱系)起源于一个由真核细胞质的古代祖先组成的联盟,这是线粒体的细菌祖先和病毒祖先 核。 从病理学的角度来看,病毒和人类之间的肽序列相似度可以在病毒感染/免疫后免疫应答期间为自身免疫交叉反应提供分子平台。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号