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首页> 外文期刊>Cytokine >Differential synthesis of two interleukin-1 receptor antagonist variants and interleukin-8 by peripheral blood neutrophils.
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Differential synthesis of two interleukin-1 receptor antagonist variants and interleukin-8 by peripheral blood neutrophils.

机译：外周血中性粒细胞差异合成两种白介素-1受体拮抗剂变体和白介素8。

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摘要

With a short lifespan and containing only few ribosomes and endoplasmic reticulum structures, neutrophils are thought to have a limited capacity for protein synthesis. We here show that peripheral blood polymorphonuclear neutrophils (PMN) are able react to stimulants with differential production of two interleukin (IL)-1 receptor antagonist (IL-1ra) isoforms, secreted IL-1ra (sIL-1ra) and the 16kDa intracellular form of IL-1ra (icIL-1ra3), as well as IL-8. Neutrophils of a high purity and with a low degree of preactivation upregulate mRNA and de novo synthesize protein of both IL-1ra variants and IL-8 in response to granulocyte-macrophage colony-stimulating factor and lipopolysaccharide. The cytokines are differentially regulated and distributed in two intracellular compartments. In comparison with peripheral blood mononuclear cells (PBMC), PMN produce distinctly more sIL-1ra but significantly less IL-8. This may indicate an anti-inflammatory role, enabling PMN to antagonize proinflammatory signals. Itis therefore possible that PMN play an important role in immune regulation by counteracting a dysregulation of the inflammatory process.
机译：嗜中性粒细胞寿命短，仅含有很少的核糖体和内质网结构，因此蛋白质合成能力有限。我们在这里显示，外周血多形核中性粒细胞（PMN）能够对刺激物产生反应，产生两种白介素（IL）-1受体拮抗剂（IL-1ra）亚型，分泌的IL-1ra（sIL-1ra）和16kDa细胞内形式IL-1ra（icIL-1ra3）和IL-8。响应粒细胞-巨噬细胞集落刺激因子和脂多糖，高纯度和低预活化度的中性粒细胞上调IL-1ra变体和IL-8的mRNA和从头合成蛋白。细胞因子被不同地调节并分布在两个细胞内区室中。与外周血单个核细胞（PBMC）相比，PMN产生明显更多的sIL-1ra，但明显减少IL-8。这可能表明有抗炎作用，使PMN能够拮抗促炎信号。因此，PMN有可能通过抵消炎症过程的失调而在免疫调节中发挥重要作用。

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