...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytokine >Elevated interleukin-12 and CXCL10 in subacute sclerosing panencephalitis.
【24h】

Elevated interleukin-12 and CXCL10 in subacute sclerosing panencephalitis.

机译：亚急性硬化性全脑炎中白介素12和CXCL10升高。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Immunosuppression associated with measles virus (MV) can be demonstrated by cytokine production failure in subacute sclerosing panencephalitis (SSPE) and may have implications on the pathogenesis of the disease. Cytokines (IL-12, IL-10, IL-4, IL-17, IL-18, IFN-alpha, IFN-gamma) and chemokines (CXCL8, CXCL10, CCL2 and CCL5) were measured in the cerebrospinal fluid (CSF) and serum samples from 60 patients with SSPE, 36 patients with infectious and/or inflammatory (IN) and 28 with other non-inflammatory (NIN) neurological diseases by ELISA. IL-12 p70+p40 was elevated in CSF and sera of SSPE when compared to the NIN group. However, the CSF levels of IL-12 p70 alone were not increased, indicating an increase of p40. The CSF of SSPE patients also showed relatively higher levels of IL-10 than that of the NIN group. CXCL10 levels in CSF were significantly higher in SSPE, whereas CXCL8 was increased in sera compared to NIN. No difference was detected in IFN-gamma, IFN-alpha, IL-17, IL-18, IL-4 or CCL2 and CCL5 levels. These results demonstrate that immune response against MV in SSPE may be impaired, although some T cell/Th1 inducing stimulations are present.
机译：亚急性硬化性全脑炎（SSPE）的细胞因子产生失败可以证明与麻疹病毒（MV）相关的免疫抑制，并且可能对疾病的发病机制有影响。在脑脊液（CSF）中测量了细胞因子（IL-12，IL-10，IL-4，IL-17，IL-18，IFN-α，γ-干扰素）和趋化因子（CXCL8，CXCL10，CCL2和CCL5） ELISA检测60例SSPE患者，36例感染和/或炎性（IN）患者和28例其他非炎性（NIN）神经系统疾病患者的血清样本。与NIN组相比，CSF和SSPE血清中IL-12 p70 + p40升高。然而，单独的IL-12 p70的CSF水平没有增加，表明p40增加。 SSPE患者的CSF也显示出比NIN组更高的IL-10水平。与NIN相比，SSPE中CSF中的CXCL10水平显着更高，而血清中CXCL8则升高。在IFN-γ，IFN-α，IL-17，IL-18，IL-4或CCL2和CCL5水平上未检测到差异。这些结果表明，尽管存在一些诱导T细胞/ Th1的刺激，但SSPE中针对MV的免疫反应可能会受损。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号