ErpC, a member of the complement regulator-acquiring family of surface proteins from Borrelia burgdorferi, possesses an architecture previously unseen in this protein family

Caesar Joseph J. E.; Johnson Steven; Kraiczy Peter; Lea Susan M.

首页> 外文期刊>Acta crystallographica, Section F. Structural biology and crystallization communications >ErpC, a member of the complement regulator-acquiring family of surface proteins from Borrelia burgdorferi, possesses an architecture previously unseen in this protein family

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ErpC, a member of the complement regulator-acquiring family of surface proteins from Borrelia burgdorferi, possesses an architecture previously unseen in this protein family

机译：ErpC是来自伯氏疏螺旋体的补体调节剂表面蛋白家族的成员，其结构在该蛋白家族中尚属未知

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Borrelia burgdorferi is a spirochete responsible for Lyme disease, the most commonly occurring vector-borne disease in Europe and North America. The bacterium utilizes a set of proteins, termed complement regulator-acquiring surface proteins (CRASPs), to aid evasion of the human complement system by recruiting and presenting complement regulator factor H on its surface in a manner that mimics host cells. Presented here is the atomic resolution structure of a member of this protein family, ErpC. The structure provides new insights into the mechanism of recruitment of factor H and other factor H-related proteins by acting as a molecular mimic of host glycosaminoglycans. It also describes the architecture of other CRASP proteins belonging to the OspE/F-related paralogous protein family and suggests that they have evolved to bind specific complement proteins, aiding survival of the bacterium in different hosts.

机译：伯氏疏螺旋体是引起莱姆病的一种螺旋体，莱姆病是欧洲和北美最常见的媒介传播疾病。该细菌利用一组称为补体调节剂的表面蛋白（CRASPs）的蛋白质，通过以模拟宿主细胞的方式在其表面募集并呈递补体调节因子H来帮助逃避人类补体系统。这里介绍的是此蛋白质家族ErpC成员的原子拆分结构。该结构通过充当宿主糖胺聚糖的分子模拟物，为募集因子H和其他因子H相关蛋白的机制提供了新见解。它还描述了属于OspE / F相关旁系蛋白家族的其他CRASP蛋白的结构，并暗示它们已经进化为结合特异性补体蛋白，从而有助于细菌在不同宿主中的存活。

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《Acta crystallographica, Section F. Structural biology and crystallization communications》 |2013年第6期|共5页
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Caesar Joseph J. E.; Johnson Steven; Kraiczy Peter; Lea Susan M.;
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1. ErpC, a member of the complement regulator-acquiring family of surface proteins from Borrelia burgdorferi, possesses an architecture previously unseen in this protein family [J] . Caesar Joseph J. E., Johnson Steven, Kraiczy Peter, Acta crystallographica, Section F. Structural biology and crystallization communications . 2013,第6期

机译：ErpC是来自伯氏疏螺旋体的补体调节剂表面蛋白家族的成员，其结构在该蛋白家族中尚属未知
2. Contribution of the Infection-Associated Complement Regulator-Acquiring Surface Protein 4 (ErpC) to Complement Resistance ofBorrelia burgdorferi [J] . ClaudiaHammerschmidt, TeresiaHallstr?m, ChristineSkerka, Developmental Immunology: Journal of Immunology Research . 2012,第20期

机译：感染相关补体调节剂获取表面蛋白4（ErpC）对Borrelia burgdorferi补体抗性的贡献。
3. Contribution of the Infection-Associated Complement Regulator-Acquiring Surface Protein 4 (ErpC) to Complement Resistance ofBorrelia burgdorferi [J] . ClaudiaHammerschmidt, TeresiaHallstr?m, ChristineSkerka, Developmental Immunology: Journal of Immunology Research . 2012,第9期

机译：感染相关补体调节剂获取表面蛋白4（ErpC）对Borrelia burgdorferi补体抗性的贡献。
4. Quantitation of Three Outer Surface Proteins From The Lyme Disease Spirochete, Borrelia Burgdorferi By Nanoparticle Capture / Multiple Reaction Monitoring-Mass Spectrometry. [C] . Paul Russo, Davide Tamburro, Claudia Fredolini, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：荔枝疾病三种外表面蛋白的定量，培斯基捕获/多反应监测质谱法通过培养基菌螺旋体，Borrelia Burgdorferi。
5. A molecular genetic investigation of the regulation of outer surface protein C in Borrelia burgdorferi: Identification and characterization of the novel regulatory protein BBD18. [D] . Hayes, Beth. 2012

机译：伯氏疏螺旋体中外表面蛋白C调控的分子遗传学研究：新型调控蛋白BBD18的鉴定和表征。
6. ErpC a member of the complement regulator-acquiring family of surface proteins from Borrelia burgdorferi possesses an architecture previously unseen in this protein family [O] . Joseph J. E. Caesar, Steven Johnson, Peter Kraiczy, 2013

机译：ErpC是来自伯氏疏螺旋体的补体调节剂表面蛋白家族的成员其结构在该蛋白家族中从未见过
7. ErpC, a member of the complement regulator-acquiring family of surface proteins from Borrelia burgdorferi, possesses an architecture previously unseen in this protein family. [O] . Caesar, JJ, Johnson, S, Kraiczy, P, 2013

机译：ErpC是来自伯氏疏螺旋体的补体调节剂表面蛋白家族的成员，该蛋白具有以前在该蛋白家族中未见过的结构。

ErpC, a member of the complement regulator-acquiring family of surface proteins from Borrelia burgdorferi, possesses an architecture previously unseen in this protein family

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