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首页> 外文期刊>Biomaterials Science >Three-dimensional printed 5-fluorouracil eluting polyurethane stents for the treatment of oesophageal cancers
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Three-dimensional printed 5-fluorouracil eluting polyurethane stents for the treatment of oesophageal cancers

机译：三维印刷5-氟尿嘧啶洗脱聚氨酯支架，用于治疗食管癌

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摘要

Oesophageal stents have been widely used to prevent occlusion or stenosis in the treatment of oesophageal cancers. However, stent restenosis caused by tumour ingrowth occurs frequently after stent placement. Incorporating anti-cancer drugs into endoluminal stents is a promising strategy to provide a sustained release of drugs to oesophageal malignant tissues while prolonging the retention of the stent and relieving dysphagia. Recognizing the potential of 3D printing to produce personalised stents with patient specific geometries, we herein report the development of a drug-loaded 3D printed stent for the sustained local delivery of 5-fluorouracil (5-FU) to treat oesophageal cancer. The 3D printed drug-eluting stents (DESs) were fabricated via fused deposition modelling using 5-FU-loaded polyurethane filament. Determination of the 5-FU in the filament and stent (>97%) confirmed that minimal degradation of the drug occurred during the thermal extrusion and 3D printing processes. The physicochemical properties of the stents were investigated using photoacoustic Fourier-transform infrared (PA-FTIR) spectrophotometry, X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA) and mechanical testing. In vitro release studies revealed that the drug-loaded stents provided a sustained release of 5-FU over a period of 110 days and allowed the constant diffusion of 5-FU when in contact with oesophageal mucosa. Furthermore, the 3D printed stents exhibited good stability following sterilization with gamma or UV irradiation, and during accelerated storage. This study demonstrates that 3D printing is a powerful tool for manufacturing DESs which could easily be customized to provide personalized, patient specific geometries and drug doses.
机译：Oesophageal支架已被广泛用于预防闭塞或狭窄治疗食管癌。然而，在支架放置后经常发生由肿瘤发起的支架再狭窄。将抗癌药物掺入内橄榄支架是一个有希望的策略，以便为食管恶性组织提供持续释放的药物，同时延长支架和缓解吞咽困难的保留。识别3D打印的潜力，以产生具有患者特定几何的个性化支架，我们在此报告了用于持续局部递送5-氟尿嘧啶（5-FU）的药物装载3D印刷支架以治疗食管癌。通过使用5-Fu负载的聚氨酯长丝通​​过熔融沉积建模制造3D印刷的药物洗脱支架（DESS）。灯丝和支架中的5-FU的测定（> 97％）证实，在热挤出和3D印刷过程中发生了最小的药物降解。使用光声傅里叶变换红外（PA-FTIR）分光光度法，X射线衍射（XRD），差示扫描量热法（DSC），热重量分析（TGA）和机械测试来研究支架的物理化学性质。体外释放研究表明，药物装载的支架在110天内提供5-FU的持续释放，并在与食管粘膜接触时允许5-FU的恒定扩散。此外，3D印刷支架在用γ或紫外线辐射灭菌之后表现出良好的稳定性，并且在加速储存期间灭菌。本研究表明，3D打印是制造DES的强大工具，可以容易地定制，以提供个性化，患者特定的几何形状和药物剂量。

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  • 来源
    《Biomaterials Science》 |2020年第23期|共12页
  • 作者

    Fouladian Paris; Kohlhagen Jarrod; Arafat Mohammad; Afinjuomo Franklin; Workman Nathan; Abuhelwa Ahmad Y.; Song Yunmei; Garg Sanjay; Blencowe Anton;

  • 作者单位

    Univ South Australia Clin &

    Hlth Sci Pharmaceut Innovat &

    Dev PIDG Gmup Adelaide SA 5000 Australia;

    Univ South Australia Clin &

    Hlth Sci Appl Chem &

    Translat Biomat ACTB Grp Adelaide SA 5000 Australia;

    Univ South Australia Clin &

    Hlth Sci Pharmaceut Innovat &

    Dev PIDG Gmup Adelaide SA 5000 Australia;

    Univ South Australia Clin &

    Hlth Sci Pharmaceut Innovat &

    Dev PIDG Gmup Adelaide SA 5000 Australia;

    Univ South Australia Clin &

    Hlth Sci Appl Chem &

    Translat Biomat ACTB Grp Adelaide SA 5000 Australia;

    Flinders Univ S Australia Coll Med &

    Publ Hlth Discipline Clin Pharmacol Bedford Pk SA 5042 Australia;

    Univ South Australia Clin &

    Hlth Sci Pharmaceut Innovat &

    Dev PIDG Gmup Adelaide SA 5000 Australia;

    Univ South Australia Clin &

    Hlth Sci Pharmaceut Innovat &

    Dev PIDG Gmup Adelaide SA 5000 Australia;

    Univ South Australia Clin &

    Hlth Sci Appl Chem &

    Translat Biomat ACTB Grp Adelaide SA 5000 Australia;

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  • 正文语种 eng
  • 中图分类 分子生物学;
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