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首页> 外文期刊>Biomaterials Science >Tumor-targeting multi-shelled hollow nanospheres as drug loading platforms for imaging-guided combinational cancer therapy
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Tumor-targeting multi-shelled hollow nanospheres as drug loading platforms for imaging-guided combinational cancer therapy

机译：肿瘤靶向多壳中空纳米球，作为用于成像引导的组合癌症治疗的药物装载平台

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In this work, we developed multi-shelled hollow nanospheres [RGD@a(m)-ZnO@CuO@Au@DOX HNSs] as multifunctional therapeutic agents to achieve effective and targeted Zn2+/Cu2+ therapy, induced drug delivery under low pH/red-light conditions, and enhanced phototherapy under single red-light. The photothermal and photodynamic performance of a(m)-ZnO@CuO@Au HNSs was enhanced relative to that of a(m)-ZnO nanoparticles (NPs) or a(m)-ZnO@CuO HNSs by utilizing the resonance energy transfer process and broad red-light absorption. The pH-sensitive a(m)-ZnO@CuO@Au HNSs were dissolved to Zn2+/Cu2+ in the acidic endosomes/lysosomes of cancer cells, resulting in a cancer cell killing effect. The release performance of doxorubicin (DOX) from RGD@a(m)-ZnO@CuO@Au@DOX HNSs was evaluated under low pH and red-light-irradiated conditions, and targeting of HNSs was confirmed by dual-modal imaging (magnetic resonance/fluorescence) of the tumor area. Moreover, in vivo synergistic therapy using RGD@a(m)-ZnO@CuO@Au@DOX HNSs was further evaluated in mice bearing human pulmonary adenocarcinoma (A549) cells, achieving a remarkable synergistic antitumor effect superior to that obtained by monotherapy. This study validated that RGD@a(m)-ZnO@CuO@Au@DOX HNSs can be a promising candidate for efficient postoperative cancer therapy.
机译：在这项工作中，我们开发了多壳中空纳米球[RGD @ A（M）-ZnO @ CuO @ Au @ Dox HNSS]作为多功能治疗剂，以实现有效和靶向Zn2 + / Cu2 +治疗，在低pH /红色下诱导药物递送 - 单红光下的条件和增强的光疗法。通过利用共振能量转移过程宽红光吸收。将pH敏感的A（m）-zNO @ cuo / znO @ cuo @ au hnss溶解在癌细胞的酸性底体/溶酶体中溶解于Zn2 + / Cu2 +，导致癌细胞杀伤效果。在低pH和红光照射条件下评估来自RGD @ a（m）-zno @ cuo @ -u @ dox hnss的多柔比星（dox）的释放性能，并通过双模成像确认HNSS的靶向（磁性）肿瘤区域的共振/荧光。此外，在使用RGD @ A（m）-ZnO @ CuO @ -U @ Dox HNS的体内协同疗法中，在携带人肺腺癌（A549）细胞的小鼠中进一步评估了Au @ Dox HNS，从而实现了通过单疗法获得的显着的协同抗肿瘤作用。这项研究验证了RGD @ a（m）-zno @ cuo @ au @ dox hnss可以是高效术后癌症治疗的有希望的候选者。

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