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首页> 外文期刊>Biomaterials Science >Robust alginate/hyaluronic acid thiol-yne click-hydrogel scaffolds with superior mechanical performance and stability for load-bearing soft tissue engineering
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Robust alginate/hyaluronic acid thiol-yne click-hydrogel scaffolds with superior mechanical performance and stability for load-bearing soft tissue engineering

机译:强大的海藻酸盐/透明质酸硫醇-NYNE点击水凝胶支架,具有卓越的机械性能和承载载荷软组织工程的稳定性

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摘要

Hydrogels based on hyaluronic acid (HA) exhibit great potential as tissue engineering (TE) scaffolds as a consequence of their unique biological features. Herein, we examine how the advantages of two natural polymers (i.e. HA and alginate) are combined with the efficiency and rapid nature of the thiol-yne click chemistry reaction to obtain biocompatible matrices with tailored properties. Our injectable click-hydrogels revealed excellent mechanical performance, long-term stability, high cytocompatibility and adequate stiffness for the targeted application. This simple approach yielded HA hydrogels with characteristics that make them suitable for applications as 3D scaffolds to support and promote soft tissue regeneration.
机译:基于透明质酸(HA)的水凝胶是由于其独特的生物学特征的组织工程(TE)支架的巨大潜力。 在此,我们研究了两个天然聚合物(即HA和海藻酸盐)的优点是如何与硫醇-YNE点击化学反应的效率和快速性结合,以获得具有量身定制的生物相容性基质。 我们的可注射点击水凝胶显示出优异的机械性能,长期稳定性,高细胞相容性和靶向应用的足够刚度。 这种简单的方法产生了HA水凝胶,具有使其适用于作为3D支架的应用,以支持和促进软组织再生。

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  • 来源
    《Biomaterials Science》 |2020年第1期|共8页
  • 作者单位

    Univ Birmingham Edgbaston Sch Chem Birmingham B15 2TT W Midlands England;

    Univ Manchester Div Cell Matrix Biol &

    Regenerat Med Sch Biol Sci Fac Biol Med &

    Hlth Manchester Acad Hlth Sci Ctr Manchester M13 9PT Lancs England;

    Univ Birmingham Edgbaston Sch Chem Birmingham B15 2TT W Midlands England;

    Univ Manchester Div Cell Matrix Biol &

    Regenerat Med Sch Biol Sci Fac Biol Med &

    Hlth Manchester Acad Hlth Sci Ctr Manchester M13 9PT Lancs England;

    Univ Manchester Div Cell Matrix Biol &

    Regenerat Med Sch Biol Sci Fac Biol Med &

    Hlth Manchester Acad Hlth Sci Ctr Manchester M13 9PT Lancs England;

    Univ Birmingham Edgbaston Sch Chem Birmingham B15 2TT W Midlands England;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
  • 关键词

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