Synthesis and function of amphiphilic glucan dendrimers as nanocarriers for protein delivery

Takeda Shigeo; Nishimura Tomoki; Umezaki Kaori; Kubo Akiko; Yanase Michiyo; Sawada Shin-ichi; Sasaki Yoshihiro; Akiyoshi Kazunari

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Synthesis and function of amphiphilic glucan dendrimers as nanocarriers for protein delivery

机译：两亲葡聚糖树枝状大分子作为蛋白质递送纳米载体的合成与功能

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We report the combined enzymatic synthesis of five glucan dendrimers with control of molecular weight and particle size. Amphiphilic properties were introduced through dodecyl group substitution. A Tokyo-green fluorescence assay showed that amphiphilic glucan dendrimers were able to successfully deliver active -galactosidase to cells.

机译：我们报告了五种葡聚糖树枝状大分子的组合合成，具有对分子量和粒度的控制。通过十二烷基取代引入两亲性质。东京绿色荧光测定显示两亲血糖树枝状大分子能够成功地将活性 - 高烷基酶加入细胞。

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《Biomaterials Science》 |2019年第4期|共6页
作者
Takeda Shigeo; Nishimura Tomoki; Umezaki Kaori; Kubo Akiko; Yanase Michiyo; Sawada Shin-ichi; Sasaki Yoshihiro; Akiyoshi Kazunari;
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作者单位

Kyoto Univ Grad Sch Engn Dept Polymer Chem Nishikyo Ku Kyoto 6158510 Japan;

Kyoto Univ Grad Sch Engn Dept Polymer Chem Nishikyo Ku Kyoto 6158510 Japan;

Kyoto Univ Grad Sch Engn Dept Polymer Chem Nishikyo Ku Kyoto 6158510 Japan;

Ezaki Glico Co Ltd Inst Hlth Sci Nishiyodogawa Ku 4-6-5 Utajima Osaka 5558502 Japan;

Ezaki Glico Co Ltd Inst Hlth Sci Nishiyodogawa Ku 4-6-5 Utajima Osaka 5558502 Japan;

Kyoto Univ Grad Sch Engn Dept Polymer Chem Nishikyo Ku Kyoto 6158510 Japan;

Kyoto Univ Grad Sch Engn Dept Polymer Chem Nishikyo Ku Kyoto 6158510 Japan;

Kyoto Univ Grad Sch Engn Dept Polymer Chem Nishikyo Ku Kyoto 6158510 Japan;

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正文语种 eng
中图分类分子生物学;
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1. Synthesis and function of amphiphilic glucan dendrimers as nanocarriers for protein delivery [J] . Takeda Shigeo, Nishimura Tomoki, Umezaki Kaori, Biomaterials Science . 2019,第4期

机译：两亲葡聚糖树枝状大分子作为蛋白质递送纳米载体的合成与功能
2. Organic solvent-free low temperature method of preparation for self assembled amphiphilic poly(epsilon-caprolactone)-poly(ethylene glycol) block copolymer based nanocarriers for protein delivery [J] . Payyappilly Sanal Sebastian, Panja Sudipta, Mandal Pijush, Colloids and Surfaces, B. Biointerfaces . 2015,第Null期

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3. Dendrimer-like AB(2)-type star polymers as nanocarriers for doxorubicin delivery to breast cancer cells: synthesis, characterization, in-vitro release and cytotoxicity studies [J] . Journal of Polymer Research . 2020,第7期

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4. Folate-Functionalized Unimolecular Micelles Based on a Biodegradable Amphiphilic Dendrimer-Like Star Polymer for Tumor-Targeted Drug Delivery [C] . Weiqiang Cao, Jing Zhou, Yong Wang PMSE Symposia . 2011

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5. Synthesis and characterization of amphiphilic iron(4)sulfur(4)-core dendrimers as protein models. [D] . Kim, Namjin. 2006

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6. Synthesis of New Functionalized Citric Acid-based Dendrimers as Nanocarrier Agents for Drug Delivery [O] . Hassan Namazi, Sanaz Motamedi, Mina Namvari 2011

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7. Amphiphilic dendrimer engineered nanocarrier systems for co-delivery of siRNA and paclitaxel to matrix metalloproteinase-rich tumors for synergistic therapy [O] . Xin Li, A-ning Sun, Yu-jie Liu, 2018

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Synthesis and function of amphiphilic glucan dendrimers as nanocarriers for protein delivery

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