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首页> 外文期刊>Biomaterials Science >Bio-engineered cell membrane nanovesicles as precision theranostics for perihilar cholangiocarcinoma
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Bio-engineered cell membrane nanovesicles as precision theranostics for perihilar cholangiocarcinoma

机译：生物工程化细胞膜纳米粒子作为皮膜胆管癌的精密治疗剂

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Perihilar cholangiocarcinoma (PHCC) presents a formidable challenge due to its occult anatomic location, aggressive growth, insensitivity to conventional chemotherapy, and poor prognosis. Herein, we engineered a human epidermal growth factor receptor 2 (HER2) affibody to the surface of cell membrane nanovesicles (A-NVs) in a ligand-oriented manner and loaded them with indocyanine green (ICG) as precision theranostics for PHCC treatment. The A-NVs@ICG were prepared and exhibited satisfactory targeting effects in HER2-overexpressing PHCC cells. In vivo fluorescence and photoacoustic imaging demonstrated that A-NVs@ICG promoted the accumulation of ICG in PHCC tissue, leading to enhanced tumor regression and improved anti-cancer effects when combined with photoirradiation. Therefore, bio-engineered A-NVs@ICG represent a promising nanotheranostic agent for PHCC with potential for clinical translation.
机译：PeriwilliCocarcinoma（PHCC）由于其隐匿的解剖学位置，伴随增长，对常规化疗不敏感，预后差而具有巨大挑战。 在此，我们以配体为导向的方式设计了人表皮生长因子受体2（HER2）对细胞膜纳米粒子（A-NVS）的表面粘合，并用吲哚菁绿（ICG）作为PHCC处理的精确治疗。 制备A-NVS @ ICG并在HER2过表达PHCC细胞中表现出令人满意的靶向效果。 体内荧光和光声成像证明A-NVS @ ICG促进了ICG在PHCC组织中的积累，导致肿瘤回归和改善与光放射相结合时改善抗癌效果。 因此，生物学工程A-NVS @ ICG代表了具有临床翻译潜力的PHCC的有希望的纳米移植剂。

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