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首页> 外文期刊>Biomaterials Science >A facile and universal strategy to endow implant materials with antibacterial ability via alkalinity disturbing bacterial respiration
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A facile and universal strategy to endow implant materials with antibacterial ability via alkalinity disturbing bacterial respiration

机译：通过碱度扰乱细菌呼吸来赋予植入物质的容易和普遍的策略来赋予抗菌能力

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摘要

Multifarious strategies have been proposed to enhance the antibacterial ability of implant surfaces for preventing bacterial infection, however, developing facile and universal modification methods still remains extremely elusive. Herein, inspired by the fact that the electron transfer respiratory chain of bacteria is embedded in the membrane, we proposed a novel strategy of local alkalinity disturbing bacterial respiration to endow implant materials with antibacterial ability. As a demonstration, MgO was deposited on biomedical titanium via magnetron sputtering to regulate surface alkalinity. With the thickness of MgO films increasing, they exhibited an excellent antibacterial rate against both Gram-negative and positive bacteria. The antibacterial mechanism confirmed that the alkaline surface can disturb the bacterial respiration action via weakening the transmembrane proton concentration gradient, resulting in the blockage of energy metabolism and the increase of oxidative stress of bacteria. Cell experiments indicated that MgO films not only have no obvious cytotoxicity to osteoblast cells, but can also selectively kill bacteria and promote cell proliferation in the presence of both bacteria and cells. More importantly, the by-product of MgO was only the biocompatible Mg2+, reducing any concerns about potential toxic effects. Furthermore, sputtering alkaline MgO films was confirmed to work well on polyetheretherketone polymer and zirconia ceramic implants, which indicates that this strategy has broad prospects of clinical application for preventing implant-associated bacterial infection.
机译：已经提出了改善植入物表面以防止细菌感染的抗菌能力，然而，开发的容易和通用改性方法仍然仍然非常难以捉摸。这里的灵感灵感，因为细菌的电子转移呼吸链嵌入膜中，我们提出了一种新的局部碱度干扰细菌呼吸策略，以赋予抗菌能力的植入物。作为示范，MgO通过磁控溅射沉积在生物医学钛上以调节表面碱度。随着MgO膜的厚度增加，它们对革兰氏阴性和阳性细菌的抗菌速率表现出优异的抗菌速率。抗菌机制证实，碱性表面可以通过削弱跨膜质子浓度梯度来干扰细菌呼吸作用，从而堵塞能量代谢和细菌氧化应激的增加。细胞实验表明，MgO膜不仅对成骨细胞没有明显的细胞毒性，而且还可以选择性地杀死细菌并在细菌和细胞存在下促进细胞增殖。更重要的是，MgO的副产物仅是生物相容性Mg2 +，减少了对潜在毒性作用的任何担忧。此外，确认溅射碱性MgO膜在聚醚醚酮聚合物和氧化锆陶瓷植入物上工作，这表明该策略具有广泛的临床应用前景，用于预防植入物相关的细菌感染。

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