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首页> 外文期刊>Biomaterials Science >An osteoconductive PLGA scaffold with bioactive beta-TCP and anti-inflammatory Mg(OH)(2) to improve in vivo bone regeneration
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An osteoconductive PLGA scaffold with bioactive beta-TCP and anti-inflammatory Mg(OH)(2) to improve in vivo bone regeneration

机译：具有生物活性β-TCP和抗炎Mg（OH）（2）的骨导电PLGA支架，以改善体内骨再生

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摘要

Poly(lactic-co-glycolic acid) (PLGA) has been widely used as a biomaterial for pharmaceutical and medical applications. However, the decomposition products of PLGA are known to acidify the surrounding tissue of the implanted site, causing an inflammatory response. Previously, we developed PLGA/inorganic nanocomposites and optimized the amounts of inorganic compounds, beta-tricalcium phosphate (beta-TCP) and magnesium hydroxide [Mg(OH)(2)], in terms of osteogenesis of normal human osteoblasts and anti-inflammatory responses of preosteoclastic cells in vitro. In this study, the potential of the optimized PLGA/beta-TCP/Mg(OH)(2) nanocomposite (TCP/MH) to promote bone repair through osteoinductive, osteoconductive, and anti-inflammatory abilities was assessed using a bone defect in a rat humeral defect model. PLGA nanocomposites with or without inorganic compounds, PLGA, beta-TCP, MH, and TCP/MH were prepared through one-step bulk modification using a twin-screw extruder. The resulting TCP/MH nanocomposite successfully enhanced the bone regeneration rate for allowing complete bone defect healing with significantly suppressed inflammatory responses. Taken together, the organic and inorganic bioactive nanocomposite developed in this study, TCP/MH, is a promising material in orthopedic implantation.
机译：聚（乳酸二乙醇酸）（PLGA）已被广泛用作药物和医疗应用的生物材料。然而，已知PLGA的分解产物酸化植入部位的周围组织，从而引起炎症反应。以前，我们开发了PLGA /无机纳米复合材料，并优化了正常人骨细胞的骨质发生方面的无机化合物，β-磷酸钙（Beta-TCP）和氢氧化镁[Mg（OH）（2）]的量预粒细胞在体外的反应。在该研究中，使用骨缺陷评估了优化的PLGA /β-TCP / mg（OH）纳米复合材料（TCP / MH）的优化PLGA /β-TCP / Mg（OH）纳米复合材料（TCP / MH）的潜力，以促进骨缺陷中的骨缺损大鼠肱骨缺陷模型。使用双螺杆挤出机通过单步体改性制备具有或不具有无机化合物，PLGA，β-TCP，MH和TCP / MH的PLGA纳米复合材料。所得的TCP / MH纳米复合材料成功增强了骨再生率，以便完全骨缺损愈合显着抑制炎症反应。在一起，在本研究中发育的有机和无机生物活性纳米复合材料TCP / MH是矫形植入的有希望的材料。

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  • 来源
    《Biomaterials Science》 |2020年第3期|共12页
  • 作者

    Go Eun Jin; Kang Eun Young; Lee Seul Ki; Park Sookhyun; Kim Jae Hwa; Park Wooram; Kim Ik Hwan; Choi Bogyu; Han Dong Keun;

  • 作者单位

    CHA Univ Dept Biomed Sci 335 Pangyo Ro Seongnam 13488 Gyeonggi South Korea;

    CHA Univ Dept Biomed Sci 335 Pangyo Ro Seongnam 13488 Gyeonggi South Korea;

    CHA Univ Dept Biomed Sci 335 Pangyo Ro Seongnam 13488 Gyeonggi South Korea;

    CHA Univ CHA Bundang Med Ctr Dept Orthopaed Surg 351 Yatap Dong Seongnam 13497 Gyeonggi South Korea;

    CHA Univ CHA Bundang Med Ctr Dept Orthopaed Surg 351 Yatap Dong Seongnam 13497 Gyeonggi South Korea;

    CHA Univ Dept Biomed Sci 335 Pangyo Ro Seongnam 13488 Gyeonggi South Korea;

    Korea Univ Coll Life Sci Biotechnol 145 Anam Ro Seoul 02841 South Korea;

    CHA Univ Dept Biomed Sci 335 Pangyo Ro Seongnam 13488 Gyeonggi South Korea;

    CHA Univ Dept Biomed Sci 335 Pangyo Ro Seongnam 13488 Gyeonggi South Korea;

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  • 正文语种 eng
  • 中图分类 分子生物学;
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