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首页> 外文期刊>Biomaterials Science >Single nanoparticles as versatile phototheranostics for tri-modal imaging-guided photothermal therapy
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Single nanoparticles as versatile phototheranostics for tri-modal imaging-guided photothermal therapy

机译：单纳米粒子作为三种模拟成像引导的光热疗法的多功能光曝光

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摘要

Development of versatile phototheranostics is highly desirable for cancer theranostics. Herein, a novel organic conjugated polymer (named DPP-TT) with excellent optical properties was designed and prepared. Based on single-component DPP-TT, single DPP-TT NPs as versatile phototheranostics were developed by a simple nanoprecipitation method. The obtained NPs exhibited good water solubility, excellent biocompatibility, outstanding photostability, strong NIR-I light absorption, and appropriate NIR-II fluorescence emission. Importantly, such NPs presented high photothermal conversion efficiency. From the investigations performed in vitro and in vivo, it was observed that DPP-TT NPs show remarkable performance for cancer theranostics, benefiting from single 808 nm laser-induced tri-modal (NIR-II fluorescence/photoacoustic/thermal) imaging-guided photothermal therapy.
机译：多功能光热的发展对于癌症治疗方法非常适合。 这里，设计并制备了一种具有优异光学性质的新型有机缀合聚合物（命名为DPP-TT）。 基于单组分DPP-TT，通过简单的纳米沉淀方法开发了单组分DPP-TT NPS作为多功能光曝光。 所获得的NPS表现出良好的水溶性，优异的生物相容性，优异的光稳定性，强烈的荧光吸收，以及适当的NIR-II荧光发射。 重要的是，这种NPS呈现出高的光热转换效率。 从体外和体内进行的调查中，观察到DPP-TT NPS表现出对癌症治疗的显着性能，受益于单一808nm激光诱导的三模态（NIR-II荧光/光声/热）显影 - 引导的光热 治疗。

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  • 来源
    《Biomaterials Science》 |2019年第9期|共5页
  • 作者

    Lu Xiaomei; Chen Jiaqi; Li Jie; Xia Bing; Xu Jingzeng; Wang Qi; Xie Chen; Fan Quli; Huang Wei;

  • 作者单位

    Nanjing Tech Univ Key Lab Flexible Elect Nanjing 211816 Jiangsu Peoples R China;

    Nanjing Tech Univ Key Lab Flexible Elect Nanjing 211816 Jiangsu Peoples R China;

    Nanjing Univ Posts &

    Telecommun Key Lab Organ Elect &

    Informat Displays Nanjing 210023 Jiangsu Peoples R China;

    Nanjing Univ Posts &

    Telecommun Key Lab Organ Elect &

    Informat Displays Nanjing 210023 Jiangsu Peoples R China;

    Nanjing Univ Posts &

    Telecommun Key Lab Organ Elect &

    Informat Displays Nanjing 210023 Jiangsu Peoples R China;

    Nanjing Univ Posts &

    Telecommun Key Lab Organ Elect &

    Informat Displays Nanjing 210023 Jiangsu Peoples R China;

    Nanjing Univ Posts &

    Telecommun Key Lab Organ Elect &

    Informat Displays Nanjing 210023 Jiangsu Peoples R China;

    Nanjing Univ Posts &

    Telecommun Key Lab Organ Elect &

    Informat Displays Nanjing 210023 Jiangsu Peoples R China;

    Nanjing Tech Univ Key Lab Flexible Elect Nanjing 211816 Jiangsu Peoples R China;

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  • 正文语种 eng
  • 中图分类 分子生物学;
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