Logical stimuli-triggered delivery of small molecules from hydrogel biomaterials

Ruskowitz Emily R.; Comerford Michael P.; Badeau Barry A.; DeForest Cole A.

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Logical stimuli-triggered delivery of small molecules from hydrogel biomaterials

机译：从水凝胶生物材料中触发逻辑刺激递送小分子

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Stimuli-responsive biomaterials are useful platforms for environmentally triggered drug delivery. By varying the molecular architecture of orthogonal stimuli-labile linkages between small molecules and non-degradable materials, we demonstrate the Boolean logic-based release of model therapeutics from gels. Programmable responses are demonstrated for materials sensitive to input combinations involving enzymes, chemical reductants, and light via YES, OR, and AND logic gates.

机译：刺激响应性生物材料是用于环保触发药物递送的有用平台。通过改变小分子和不可降解材料之间的正交刺激键的分子结构，我们展示了从凝胶的模型治疗的基于布尔逻辑的释放。对涉及酶，化学还原剂和光的输入组合敏感的材料证明了可编程响应，通过是，和和逻辑门的输入组合。

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来源
《Biomaterials Science》 |2019年第2期|共5页
作者
Ruskowitz Emily R.; Comerford Michael P.; Badeau Barry A.; DeForest Cole A.;
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Univ Washington Dept Chem Engn 3781 Okanogan Lane NE Seattle WA 98195 USA;

Univ Washington Dept Chem Engn 3781 Okanogan Lane NE Seattle WA 98195 USA;

Univ Washington Dept Chem Engn 3781 Okanogan Lane NE Seattle WA 98195 USA;

Univ Washington Dept Chem Engn 3781 Okanogan Lane NE Seattle WA 98195 USA;

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正文语种 eng
中图分类分子生物学;
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1. Logical stimuli-triggered delivery of small molecules from hydrogel biomaterials [J] . Ruskowitz Emily R., Comerford Michael P., Badeau Barry A., Biomaterials Science . 2019,第2期

机译：从水凝胶生物材料中触发逻辑刺激递送小分子
2. Genipin-cross-linked hydrogels based on biomaterials for drug delivery: a review [J] . Yibin Yu, Shuo Xu, Sanming Li, Biomaterials Science . 2021,第5期

机译：基于生物材料的Genipin-交联水凝胶：审查
3. BIOMATERIAL BASED INJECTABLE HYDROGEL FOR CONTROLLED DRUG DELIVERY: A REVIEW [J] . S. S. Bhujbal, S. B. Darade, S. S. Dharmadhikari International Journal of Pharmaceutical Sciences and Research . 2020,第3期

机译：受控药物交付的生物材料注射水凝胶：综述
4. Logical Stimuli-Triggered Delivery of Small Molecules from Hydrogel Biomaterials [C] . Emily R. Ruskowitz, Michael P. Comerford, Barry A. Badeau, Society for Biomaterials annual meeting and exposition . 2019

机译：从水凝胶生物材料中逻辑触发的小分子传递。
5. The synthesis and characterization of novel biomaterials from natural building blocks: Biomaterials research: Past, present, and future directions, and, Saccharide-derived polymers as protein resistant biomaterials, and, Saccharide-peptide copolymers for gene delivery applications, and, Saccharide-peptide copolymer hydrogels for extracellular scaffold design. [D] . Metzke, Mark Adam. 2006

机译：从天然构件中合成和表征新型生物材料：生物材料研究：过去，现在和未来的方向，以及，糖衍生的聚合物作为抗蛋白质生物材料，以及用于基因传递应用的糖肽共聚物，以及糖肽共聚物水凝胶用于细胞外支架设计。
6. Corrigendum to Sustained localized presentation of RNA interfering molecules from in situ forming hydrogels toguide stem cell osteogenic differentiation Biomaterials 35/24 (2014) 6278–6286 [O] . Minh K. Nguyen, Oju Jeon, Melissa D. Krebs, -1

机译：原位形成水凝胶的RNA干扰分子的持续局部表达的勘误指导干细胞成骨分化生物材料35/24（2014）6278-6286
7. Corrigendum to “Sustained localized presentation of RNA interfering molecules from in situ forming hydrogels to guide stem cell osteogenic differentiation” Biomaterials 35/24 (2014) 6278–6286 [O] . Minh K. Nguyen, Oju Jeon, Melissa D. Krebs, 2017

机译：勘探为“来自原位形成水凝胶的RNA干扰分子的持续局部呈现，以引导干细胞骨质发生分化”生物材料35/24（2014）6278-6286

Logical stimuli-triggered delivery of small molecules from hydrogel biomaterials

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