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首页> 外文期刊>Biological psychiatry >Behavioral and Neural Sustained Attention Deficits in Bipolar Disorder and Familial Risk of Bipolar Disorder
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Behavioral and Neural Sustained Attention Deficits in Bipolar Disorder and Familial Risk of Bipolar Disorder

机译：双相情感障碍的行为和神经持续注意缺陷和双相障碍的家族风险

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Abstract Background Few neuroimaging studies compare individuals affected with bipolar disorder (BP), at high familial risk of BP, and at low risk to identify endophenotypes for BP. None have examined variability in attention, despite promising behavioral work in this area. We used functional magnetic resonance imaging (fMRI) methods uniquely powered to compare the neural correlates of attention variability in these three groups. Methods The present study examined 8- to 25-year-old individuals ( n = 106) who completed an fMRI attention task: 24 with BP, 29 at risk based on a first-degree relative with BP, and 53 healthy, low-risk individuals. Group differences in intrasubject variability in reaction time were examined, and a sophisticated fMRI analytic approach was used to quantify precisely trialwise associations between reaction time and brain activity. The latter has not been examined previously in BP or risk of BP. Results Relative to healthy individuals, those with BP or at risk for BP exhibited increased reaction time variability ( F 2,102 = 4.26, p = .02, η p 2 = .08). Importantly, we identified blunted relationships between trialwise variation in reaction time and brain activity in the inferior and middle frontal gyri, precuneus, cingulate cortex, caudate, and postcentral gyrus (all regions: p p 2 > .06) in both at-risk and BP individuals compared with healthy, low-risk individuals. This blunting partially mediated group differences in reaction time variability (β = .010, 95% confidence interval 0.002 to 0.020, Sobel Z = 2.08, p = .038). Conclusions Blunting in key frontal, cingulate, and striatal areas was evident in unaffected, at-risk individuals and in euthymic BP patients. Elucidating such novel neural endophenotypes can facilitate new approaches to BP prediction, diagnosis, and prevention.
机译：摘要背景少数神经影像画研究比较患有双相情感障碍（BP）的个体，在BP的高处理风险，并且低风险以识别BP的内心型。尽管在这方面有希望的行为工作，但无需检查的可变性。我们使用功能磁共振成像（FMRI）方法唯一地供电，以比较这三个组中的注意力变异性的神经相关性。方法本研究审查了8至25岁的人（n = 106），他们完成了FMRI注意任务：24，BP，29个以与BP的一定程度相对的风险为基础，53个健康，低风险个人。研究了反应时间内肠内胆碱可变异性的组差异，并且使用复杂的FMRI分析方法来定量反应时间和大脑活动之间的试验性缔合。后者尚未以前在BP或BP的风险中进行检查。结果相对于健康个体，具有BP或BP风险的结果表现出反应时间变化增加（F 2,102 = 4.26，P = .02，ηp2 = .08）。重要的是，我们在劣质和中间吉尔里，前阶段吉尔蒂，前阶段吉尔里，刺痛皮层，尾部（所有地区：PP 2> .06）中的反应时间和脑活动中的反应时间和脑活动中的反应时间和大脑活动之间的钝化关系个人与健康，低风险的个体相比。这种钝化部分介导的局部介导的反应时间变异性（β= .010,95％置信区间0.002至0.020，Sobel Z = 2.08，P = .038）。结论在关键的正面，挤压和纹状体地区钝化在不受影响的，风险的个体和局部的BP患者中是明显的。阐明这种新型神经内卵素可以促进BP预测，诊断和预防的新方法。

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