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The influence of a TNF gene polymorphism on the severity of rheumatoid arthritis in the Brazilian Amazon

机译：TNF基因多态性对巴西亚马逊地区类风湿关节炎严重程度的影响

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Purpose: The aim of this study was to investigate the influence of the TNF -308 G/A polymorphism in the promoter region of the tumor necrosis factor- ?? gene on the susceptibility and severity of rheumatoid arthritis (RA) in individuals from the Brazilian Amazon. Methods: A total of 323 individuals-192 healthy controls without arthritis and 131 individuals suffering from arthritis-were genotyped for this polymorphism using a methodology based on PCR-RFLP. Results: The frequency of the A allele (TNF2) in rheumatoid arthritis sufferers was not significantly higher than in the controls (p= 0.926; OR = 0.97; confidence interval 0.54-1.76). However, using a logistic regression model, when the patients were stratified according to whether the manifestations were preponderantly articular or systemic, there was a strong association between the TNF2 allele and systemic arthritis (p= 0.001; OR = 5.89; confidence interval = 1.98-17.5) as well as the use of anti-TNF immunotherapy (p= 0.023; OR = 1.10; confidence interval = 1.00-1.14). The main factors that were found to influence the risk of extra-articular disease were age greater than or equal to 60. years (p= 0.008; OR = 4.06; confidence interval = 1.45-11.38), disease duration greater than 10. years (p= 0.031; OR = 3.10; confidence interval = 1.11-8.63) and positive rheumatoid factor (p= 0.035; OR = 2.07; confidence interval = 1.05-4.09). Conclusions: These results suggest that the TNF2 allele is associated with the more serious forms of the disease in individuals from the Brazilian Amazon but not with a risk for developing RA. ? 2012 Elsevier Ltd.
机译：目的：本研究的目的是研究TNF -308 G / A多态性对肿瘤坏死因子-β启动子区的影响。巴西亚马逊地区个体中类风湿关节炎（RA）的易感性和严重性相关基因。方法：使用基于PCR-RFLP的方法，对323名个体（192名无关节炎的健康对照者和131名患有关节炎的个体）进行了多态性基因分型。结果：类风湿关节炎患者的A等位基因（TNF2）频率没有明显高于对照组（p = 0.926; OR = 0.97;置信区间0.54-1.76）。然而，使用逻辑回归模型，当根据表现主要是关节还是全身来对患者进行分层时，TNF2等位基因与全身性关节炎之间有很强的关联性（p = 0.001; OR = 5.89;置信区间= 1.98- 17.5）以及抗TNF免疫疗法的使用（p = 0.023; OR = 1.10;置信区间= 1.00-1.14）。发现影响关节外疾病风险的主要因素是年龄大于或等于60.岁（p = 0.008; OR = 4.06;置信区间= 1.45-11.38），疾病持续时间大于10年（ p ＝ 0.031; OR ＝ 3.10;置信区间＝ 1.11-8.63）和类风湿因子为正（p ＝ 0.035; OR ＝ 2.07;置信区间＝ 1.05-4.09）。结论：这些结果表明，TNF2等位基因与来自巴西亚马逊河地区的个体的更严重形式的疾病有关，但没有发展为RA的风险。 ？ 2012爱思唯尔有限公司

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