...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytokine >Vitamin D3 supplementation modulates inflammatory responses from the muscle damage induced by high-intensity exercise in SD rats
【24h】

Vitamin D3 supplementation modulates inflammatory responses from the muscle damage induced by high-intensity exercise in SD rats

机译：补充维生素D3可调节SD大鼠高强度运动引起的肌肉损伤引起的炎症反应

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Vitamin D is an important factor for calcium and phosphorus homeostasis. A negative relationship has been observed between vitamin D status and diseases such as cancer, arthritis, diabetes, and muscle fiber atrophy. However, the relationship between vitamin D and prevention of skeletal muscle damage has not been clearly elucidated. The purpose of this study was to investigate the effects of vitamin D on exercise-induced muscle changes. Rats were divided into 3 groups: (1) sedentary control (C: n= 10), (2) high-intensity exercise (HE: n= 10), and (3) high-intensity exercise with vitamin D supplementation (HED: n= 10; i.p. 1000. IU/kg body weight). Rats were trained for 30. min/day on treadmills (5. days/week for 8. weeks) with the running speed gradually increased up to 30. m/min at a 3° incline. At the end of the training period, the running speed was 38. m/min at a 5° incline. The high-intensity exercise significantly increased plasma creatine kinase (CK) and lactate dehydrogenase (LDH) activity. In addition, IL-6 and TNF-α levels as well as phosphorylation of AMPK, p38, ERK1/2, IKK, and IκB were significantly increased. Vitamin D-treated rats showed a significant decrease in plasma CK level, phosphorylation of AMPK, p38, ERK1/2, IKK, and IκB, and gene expression of IL-6 and TNF-α. Furthermore, the protein expression of vitamin D receptor (VDR) was highly increased in the muscles of HED-treated rats, respectively. Therefore, we concluded that vitamin D may play a pivotal role in exercise-induced muscle damage and inflammation through the modulation of MAPK and NF-κB involved with VDR.
机译：维生素D是钙和磷稳态的重要因素。维生素D状况与癌症，关节炎，糖尿病和肌纤维萎缩等疾病之间存在负相关关系。但是，维生素D与预防骨骼肌损伤之间的关系尚未明确阐明。这项研究的目的是研究维生素D对运动引起的肌肉变化的影响。大鼠分为3组：（1）久坐对照（C：n = 10），（2）高强度运动（HE：n = 10）和（3）补充维生素D的高强度运动（HED： n ＝ 10; ip1000。IU/ kg体重）。大鼠在跑步机上训练30分钟/天（5天/周，共8周），跑步速度逐渐增加，倾斜3度时达到30 m / min。在训练期结束时，在5°倾斜的情况下，跑步速度为38. m / min。高强度运动可显着提高血浆肌酸激酶（CK）和乳酸脱氢酶（LDH）的活性。此外，IL-6和TNF-α水平以及AMPK，p38，ERK1 / 2，IKK和IκB的磷酸化也显着增加。维生素D处理的大鼠血浆CK水平，AMPK，p38，ERK1 / 2，IKK和IκB的磷酸化以及IL-6和TNF-α的基因表达显着降低。此外，维生素D受体（VDR）的蛋白质表达在HED治疗的大鼠的肌肉中分别大大增加。因此，我们得出结论，维生素D通过调节VDR参与的MAPK和NF-κB的调节，可能在运动引起的肌肉损伤和炎症中起关键作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号