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Measuring Light at Night and Melatonin Levels in Shift Workers: A Review of the Literature

机译：在夜间和褪黑激素水平的夜间测量光线次数：对文学的审查

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Shift work, especially that involving rotating and night shifts, is associated with an increased risk of diseases, including cancer. Attempts to explain the association between shift work and cancer in particular have focused on the processes of melatonin production and suppression. One hypothesis postulates that exposure to light at night (LAN) suppresses melatonin, whose production is known to slow the development of cancerous cells, while another proposes that circadian disruption associated with shift work, and not just LAN, increases health risks. This review focuses on six studies that employed quantitative measurement of LAN and melatonin levels to assess cancer risks in shift workers. These studies were identified via searching the PubMed database for peer-reviewed, English-language articles examining the links between shift work, LAN, and disease using the terms light at night, circadian disruption, health, risk, cancer, shift work, or rotating shift. While the results indicate a growing consensus on the relationship between disease risks (particularly cancer) and circadian disruption associated with shift work, the establishment of a direct link between LAN and disease has been impeded by contradictory studies and a lack of consistent, quantitative methods for measuring LAN in the research to date. Better protocols for assessing personal LAN exposure are required, particularly those employing calibrated devices that measure and sample exposure to workplace light conditions, to accurately assess LAN's effects on the circadian system and disease. Other methodologies, such as measuring circadian disruption and melatonin levels in the field, may also help to resolve discrepancies in the findings.
机译：转移工作，特别是涉及旋转和夜班的换档，与疾病的风险增加有关，包括癌症。试图解释换档工作与癌症之间的关联，特别是褪黑素产生和抑制的过程。一个假设假设晚上暴露在夜晚（LAN）抑制褪黑激素，其产生的众所周知会减缓癌细胞的发育，而另一项提出与转移工作相关的昼夜周振，而不仅仅是局域网，增加了健康风险。本综述重点介绍六项研究，这些研究采用了局域网和褪黑激素水平的定量测量，以评估转向工人的癌症风险。这些研究是通过搜索PubMed数据库进行同行评审，英语文章来检查换档工作，兰和疾病之间的链接，使用夜间光线，昼夜振荡，健康，风险，癌症，换档工作或旋转转移。虽然结果表明对与转移工作相关的疾病风险（特别是癌症）和昼夜人之间的关系的越来越多的共识，但矛盾的研究和缺乏一致的定量方法阻碍了LAN和疾病之间的直接联系的建立测量LAN在研究迄今为止。需要更好的用于评估个人LAN暴露的协议，特别是那些使用校准设备的校准设备，测量和样品暴露在工作场所光线条件下，以准确评估LAN对昼夜节律系统和疾病的影响。其他方法，例如测量该领域中的昼夜循环和褪黑激素水平，也可能有助于解决调查结果的差异。

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