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首页> 外文期刊>Biological research for nursing >Plasma and Urinary Oxytocin Trajectories in Extremely Premature Infants During NICU Hospitalization
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Plasma and Urinary Oxytocin Trajectories in Extremely Premature Infants During NICU Hospitalization

机译：尼苏住院期间极早婴儿的血浆和尿催产素轨迹

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Extremely premature infants are at great risk for poor neurodevelopmental outcomes, in part because neurologic structures designed to mature in the womb must now do so in the extrauterine environment. Reliable biomarkers of neurodevelopment are especially critical in this population, as behavioral measures can be unreliable due to immaturity of the premature infant nervous system. Oxytocin (OT) has the potential to be a marker of neurobiological processes that offer infant neuroprotection. However, no studies have measured OT in the plasma and urine of premature infants. The purposes of this study were to describe plasma and urine OT levels of premature infants through 34 weeks corrected gestational age (CGA), determine whether plasma and urine OT are correlated, and explore associations between infant demographics and OT trajectories. Plasma and urine from 37 premature infants, born at gestational ages 25–28 6/7 weeks, were longitudinally collected at 14 days of life, then weekly until 34 weeks CGA. Plasma OT decreased with age, at a rate of 15% per week, and exhibited strong stability within infants. Urine OT was not correlated with plasma OT and did not show a significant trend over time; thus, urine may not be a reliable, noninvasive measurement in this population. Apgar score was the only infant demographic characteristic associated with plasma OT. Given the novelty of this work, replication is needed to confirm these findings, and future research should explore potential mechanisms (e.g., stress, normal maturation, and social experiences) that contribute to declining plasma OT levels in premature infants.
机译：由于神经发作的结果不佳的婴儿，部分原因是缺乏神经发育成果的风险，部分是因为在子宫内成熟的神经系统结构现在必须在Impertutine环境中这样做。神经发育的可靠生物标志物在该群群中尤为重要，因为由于早产儿神经系统的不成熟，行为措施可能是不可靠的。催产素（OT）有可能成为提供婴儿神经保护的神经生物学过程的标志物。然而，没有研究过早婴儿的血浆和尿液中的OT。本研究的目的是描述通过34周矫正妊娠龄（CGA）的早产儿和尿液尿液尿液水平，确定血浆和尿液是否相关，并探索婴儿人口统计和OT轨迹之间的关联。来自37个早产儿的血浆和尿液，出生于25-28周的妊娠期25-28周，在生命的14天纵向收集，然后每周直到34周CGA。血浆OT随着年龄的增长而减少，每周15％的速率，并在婴儿的稳定性上表现出强烈的稳定性。尿液不与血浆OT相关，并且没有显示出显着的趋势;因此，尿液可能不是这种群体的可靠性，非侵入性的测量。 APGAR评分是唯一与血浆OT相关的婴儿人口统计学特征。鉴于这项工作的新颖性，需要复制来确认这些调查结果，未来的研究应该探讨潜在的机制（例如，压力，正常成熟和社会经验），这些机制有助于在早产儿的血浆OT水平下降。

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