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首页> 外文期刊>Biological research for nursing >The Effect of Moderate- Versus High-Intensity Resistance Training on Systemic Redox State and DNA Damage in Healthy Older Women
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The Effect of Moderate- Versus High-Intensity Resistance Training on Systemic Redox State and DNA Damage in Healthy Older Women

机译：中等 - 与高强度抗性训练对健康老年女性全身氧化还原态和DNA损伤的影响

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摘要

This study investigated effects of a 16-week progressive resistance training program (RTP) with elastic bands at two different intensities on systemic redox state, DNA damage, and physical function in healthy older women. Methods: Participants were randomly assigned to the high-intensity group (HIGH; n = 39), moderate-intensity group (MOD; n = 31), or control group (CG; n = 23). The exercise groups performed an RTP twice a week with three to four sets of 6 (HIGH) or 15 (MOD) repetitions of six overall body exercises at a perceived exertion rate of 8–9 on the OMNI-Resistance Exercise Scale for use with elastic bands. Thiol redox state was determined by reduced glutathione (GSH), oxidized glutathione (GSSG), and GSSG/GSH in blood mononuclear cells. Degree of DNA damage was assessed by presence of the oxidized DNA base molecule 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-OHdG) in urine. Physical function monitoring was based on the arm curl, chair stand, up and go, and 6-min walk tests. Results: The HIGH group showed a significant increase in 8-OHdG (+71.07%, effect size [ES] = 1.12) and a significant decrease in GSH (?10.91, ES = ?0.69), while the MOD group showed a significant decrease in 8-OHdG levels (?25.66%, ES = ?0.69) with no changes in thiol redox state. GSH levels differed significantly between the HIGH and CG groups posttest. The exercise groups showed significant improvements in physical function with no differences between groups. Conclusion: RTP at a moderate rather than high intensity may be a better strategy to reduce DNA damage in healthy older women while also increasing independence.
机译：本研究调查了16周的逐步阻力训练计划（RTP）对系统氧化还原状态，DNA损伤和健康老年妇女的身体功能的两种不同强度的弹性带的影响。方法：参与者被随机分配给高强度组（高; n = 39），中等强度组（mod; n = 31）或对照组（cg; n = 23）。锻炼组每周进行两次RTP，其中三组6（高）或15（MOD）重复六个整体练习，以8-9的感知速度为8-9，用于与弹性一起使用乐队。通过降低的谷胱甘肽（GSH），氧化的谷胱甘肽（GSSG）和GSSG / GSH在血液单核细胞中测定硫醇氧化铈状态。通过氧化DNA碱分子8-氧氧-7,8-二氢-2'-脱氧核苷酸（8-OHDG）的存在评估DNA损伤程度。物理功能监控基于ARM卷曲，椅子支架，上升和去，步行6分钟。结果：高基团显示出8-OHDG（+ 71.07％，效果大小，效应尺寸，GSH（α10.91，ES = 0.69）显着降低，而MOD组显示出显着降低在8-OHDG水平（α25.66％，ES = 0.69）中，没有变化的硫醇氧化铈状态。在后测试的高和CG组之间GSH水平显着不同。运动组在物理功能上显示出显着的改善，群体之间没有差异。结论：中等而不是高强度的RTP可能是降低健康老年女性的DNA损伤，同时增加独立性的更好的策略。

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