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Perceived Racial Discrimination and DNA Methylation Among African American Women in the InterGEN Study

机译：在Intergen研究中感知非洲裔美国女性的种族歧视和DNA甲基化

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Introduction: Experiences of racial discrimination have been associated with poor health outcomes. Little is known, however, about how perceived racial discrimination influences DNA methylation (DNAm) among African Americans (AAs). We examined the association of experiences of discrimination with DNAm among AA women in the Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure (InterGEN) study. Methods: The InterGEN study examines the effects of genetic and psychological factors on blood pressure among AA women and their children. Measures include the Major Life Discrimination (MLD) and the Race-Related Events (RES) scales. In the present analysis, we examined discrimination and DNAm at baseline in the InterGEN study. The 850K EPIC Illumina BeadChip was used for evaluating DNAm in this epigenome-wide association study (EWAS). Results: One hundred and fifty-two women contributed data for the RES-EWAS analysis and 147 for the MLD-EWAS analysis. Most were 30–39 years old, nonsmokers, had some college education, and had incomes p p < 10~(?5)). Conclusion: We observed significant epigenetic associations between disease-associated genes (e.g., schizophrenia, bipolar disorder, and asthma) and perceived discrimination as measured by the MLD Scale. Future health disparities research should include epigenetics in high-risk populations to elucidate functional consequences induced by the psychosocial environment.
机译：介绍：种族歧视的经验与健康结果差有关。然而，众所周知，关于感知的种族歧视如何影响非洲裔美国人（AAS）中的DNA甲基化（DNAM）。我们在血压（赤霉素）研究中，在AA妇女中审查了与DNAM歧视的经验协会。方法：Intergen研究探讨了遗传和心理因素对AA妇女及其子女血压的影响。措施包括主要寿命歧视（MLD）和与比赛相关的事件（RES）秤。在本分析中，我们在intergen研究中检查了基线的歧视和Dnam。 850K Epic Illumina Beadchip用于评估该表观植物组合研究（EWAS）中的Dnam。结果：一百五十二个女性为MLD-EWAS分析提供了Res-Ewas分析的数据和147。大多数是30-39岁，没有助手，有一些大学教育，并且收缩了P <10〜（？5））。结论：我们观察了疾病相关基因（例如，精神分裂症，双相障碍和哮喘）之间的重要表观吻合术，并通过MLD规模测量的感知歧视。未来的健康差异研究应包括高风险群体的表观遗传学，以阐明心理社会环境所引起的功能后果。

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