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Expression profiling and significance of VEGF-A, VEGFR2, VEGFR3 and related proteins in endometrial carcinoma

机译：子宫内膜癌中VEGF-A，VEGFR2，VEGFR3及相关蛋白的表达及其意义

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Background: Angiogenesis plays a key role in the progression of various tumors, including endometrial carcinomas. Several cytokines and their associated receptors are shown to be involved, particularly VEGF-A with VEGFR1, -2 and -3. Methods: The expressions of VEGF-A, VEGFR2 and VEGFR3 were studied in by immunohistochemistry in 76 endometrial carcinoma specimens. VEGFR2 and VEGFR3 receptor expression were also studied by qRT-PCR in 17 tumors in comparison to normal endometrium. The expression profiles were correlated with tumor type, grade, stage, lymphovascular invasion, disease free survival, and the expressions of other cytokine receptors (EGFR, CXCR1 and CXCR2). Results: Immunohistochemically, 63% of endometrial cancers expressed VEGF-A, 55% VEGFR2 and 26% VEGFR3. VEGFR3 was significantly correlated with tumor stage (p= 0.02), with a trend towards poorer disease free survival (p= 0.09). VEGF-A was significantly correlated with microvessel density (p< 0.01). Using qRT-PCR, increased expression of VEGFR2 (17.2-fold) and VEGFR3 (21.9-fold) was seen in endometrial carcinomas compared with normal endometrium, with significant correlations among the expression levels of VEGFR2, VEGFR3, EGFR, CXCR1 and CXCR2. Conclusion: Our study suggests that evaluation of VEGFR3 expression in tumors may provide prognostic data, and help identify patients who would best benefit from anti-angiogenic therapeutic agents. This is the first report showing correlations between the expressions levels of the different receptors.
机译：背景：血管生成在包括子宫内膜癌在内的各种肿瘤的进展中起着关键作用。已显示出与几种细胞因子及其相关受体有关，尤其是VEGFR-VEGFR1，-2和-3。方法：采用免疫组织化学方法检测76例子宫内膜癌组织中VEGF-A，VEGFR2和VEGFR3的表达。与正常子宫内膜相比，qRT-PCR还研究了17种肿瘤的VEGFR2和VEGFR3受体表达。表达谱与肿瘤类型，等级，分期，淋巴血管浸润，无病生存期以及其他细胞因子受体（EGFR，CXCR1和CXCR2）的表达相关。结果：免疫组织化学法显示，63％的子宫内膜癌表达VEGF-A，55％的VEGFR2和26％的VEGFR3。 VEGFR3与肿瘤的分期显着相关（p = 0.02），且无病生存期较差（p = 0.09）。 VEGF-A与微血管密度显着相关（p <0.01）。使用qRT-PCR，与正常子宫内膜相比，子宫内膜癌中发现VEGFR2（17.2倍）和VEGFR3（21.9倍）的表达增加，且VEGFR2，VEGFR3，EGFR，CXCR1和CXCR2的表达水平之间存在显着相关性。结论：我们的研究表明评估肿瘤中VEGFR3的表达可能提供预后数据，并有助于确定最能受益于抗血管生成治疗剂的患者。这是第一份报告，显示了不同受体表达水平之间的相关性。

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