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首页> 外文期刊>Cytokine >In situ cytokines (IL-4, IL-10, IL-12, IFN-γ) and chemokines (MCP-1, MIP-1α) gene expression in human Leishmania (Leishmania) mexicana infection
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In situ cytokines (IL-4, IL-10, IL-12, IFN-γ) and chemokines (MCP-1, MIP-1α) gene expression in human Leishmania (Leishmania) mexicana infection

机译：人利什曼原虫（Leishmania）mexicana感染中的原位细胞因子（IL-4，IL-10，IL-12，IFN-γ）和趋化因子（MCP-1，MIP-1α）基因表达

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Crucial to the defense against Leishmania is the ability of the host to mount a cell-mediated immune response capable of controlling and/or eliminating the parasite. The composition of the cell populations recruited in the early phase of the infection seems to be essential for defining the infection outcomes. The signals that initiate and regulate the early immune response and local accumulation of cell subsets in the skin are poorly understood. We previously studied the in situ expression of cytokine genes in patients with localized cutaneous leishmaniasis (LCL) caused by Leishmania ( Leishmania) mexicana. In the present study we examined in situ cytokine (IL-4, IL-10, IL-12, IFN-γ) and chemokine (MCP-1, MIP-1α) gene expression in L. ( L.) mexicana active LCL lesions, and in the delayed type hypersensitivity (DTH) skin response to Leishmania antigen in subjects with healed lesion and subclinical infection. Data regarding cytokines were similar to previous studies in patients with active LCL. There were no significant differences in the profile of cytokine and chemokine gene expression in DTH from subjects with healed or subclinical infection. IL-12 gene expression detected in both groups was similar. High expression of MCP-1 was detected in all patients with active LCL. There was no difference in the level of MCP-1 expression between the healed lesion and the subclinical infection groups ( p= 0.876). IL-12 and MCP-1 in the absence of IFN-γ might be playing a crucial role in infection outcomes at skin level.
机译：对抗利什曼原虫的防御至关重要的是宿主产生能够控制和/或消除寄生虫的细胞介导的免疫应答的能力。在感染的早期阶段募集的细胞群的组成对于确定感染的结果似乎至关重要。启动和调节早期免疫反应和皮肤细胞亚群在皮肤中局部积累的信号知之甚少。我们以前研究了由利什曼原虫（Leishmania）mexicana引起的局部皮肤利什曼病（LCL）患者的细胞因子基因的原位表达。在本研究中，我们检查了墨西哥活跃的LCL病变中原位细胞因子（IL-4，IL-10，IL-12，IFN-γ）和趋化因子（MCP-1，MIP-1α）的基因表达。 ，并且在患有病变和亚临床感染的受试者中，对利什曼原虫抗原的迟发型超敏反应（DTH）皮肤反应。关于细胞因子的数据与先前有活跃LCL患者的研究相似。患有治愈或亚临床感染的受试者在DTH中的细胞因子和趋化因子基因表达谱没有显着差异。两组中检测到的IL-12基因表达相似。在所有活动性LCL患者中均检测到MCP-1高表达。在愈合的病灶和亚临床感染组之间，MCP-1的表达水平没有差异（p = 0.876）。在缺乏IFN-γ的情况下，IL-12和MCP-1可能在皮肤感染水平上起关键作用。

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