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首页> 外文期刊>Cytokine >A single injection of polyethylene-glycol granulocyte colony-stimulating factor strongly prolongs survival of mice with systemic candidiasis.
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A single injection of polyethylene-glycol granulocyte colony-stimulating factor strongly prolongs survival of mice with systemic candidiasis.

机译：一次注射聚乙二醇粒细胞集落刺激因子可大大延长全身性念珠菌病小鼠的生存期。

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摘要

Systemic candidiasis is a life-threatening disease occurring in immunocompromized patients. Granulocyte colony-stimulating factor (G-CSF) reduces mortality in experimental invasive candidiasis. Covalent conjugation of polyethylene-glycol (peg) to proteins increases their stability and in vivo bioactivity. In this study, the effect of a single subcutaneous injection of peg-G-CSF on lethal candidiasis was assessed. This was performed in acute and chronic candidiasis models in non-neutropenic FVB/N mice. Peg-G-CSF rapidly increased circulating polymorphonuclear leukocyte (PMNL) numbers in mice, sustaining high for >4 days. Candida albicans outgrowth from kidneys of infected mice was strongly reduced after peg-G-CSF treatment (5.76 log cfu/g kidney vs 7.66 control), with absence of hyphal outgrowth and enhanced PMNL influx. Moreover, peg-G-CSF increased survival of C. albicans -infected mice, whereas efficacy of uncoupled G-CSF was obtained only after repeated treatment. These data document a potent in vivo biological effect of peg-G-CSF, resulting in strongly enhanced resistance against systemic candidiasis. Copyright 2000 Academic Press.
机译：全身性念珠菌病是一种威胁生命的疾病，发生在免疫功能低下的患者中。粒细胞集落刺激因子（G-CSF）降低了实验性侵袭性念珠菌病的死亡率。聚乙二醇（peg）与蛋白质的共价缀合增加了其稳定性和体内生物活性。在这项研究中，评估了皮下注射peg-G-CSF对致命念珠菌病的影响。这是在非中性粒细胞减少症FVB / N小鼠的急性和慢性念珠菌病模型中进行的。 Peg-G-CSF会迅速增加小鼠体内的循环多形核白细胞（PMNL）数量，并维持> 4天的高水平。 peg-G-CSF治疗后，白色念珠菌从受感染小鼠的肾脏中的分泌大量减少（5.76 log cfu / g肾脏vs 7.66对照），而没有菌丝生长和增强的PMNL流入。此外，peg-G-CSF增加了感染白色念珠菌的小鼠的存活，而未偶联的G-CSF的功效只有在重复治疗后才能获得。这些数据证明了peg-G-CSF在体内的有效生物学作用，导致对全身念珠菌病的抵抗力大大增强。版权所有2000学术出版社。

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