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Recent Advances in the Development of Novel Drug Candidates for Regulating the Secretion of Pulmonary Mucus

机译:用于调节肺部粘液分泌的新型毒品候选者的最新进展

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摘要

Hypersecretion of pulmonary mucus is a major pathophysiological feature in allergic and inflammatory respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD). Overproduction and/or oversecretion of mucus cause the airway obstruction and the colonization of pathogenic microbes. Developing a novel pharmacological agent to regulate the production and/or secretion of pulmonary mucus can be a useful strategy for the effective management of pathologic hypersecretion of mucus observed in COPD and asthma. Thus, in the present review, we tried to give an overview of the conventional pharmacotherapy for mucus-hypersecretory diseases and recent research results on searching for the novel candidate agents for controlling of pulmonary mucus hypersecretion, aiming to shed light on the potential efficacious pharmacotherapy of mucus-hypersecretory diseases.
机译:肺粘液的过度折叠是过敏性和炎症性呼吸系统疾病中的主要病理生理特征,包括哮喘和慢性阻塞性肺病(COPD)。 粘液的过产和/或过分原因导致气道阻塞和致病微生物的定植。 开发一种调节新药剂来调节肺部粘液的生产和/或分泌可以是有效管理在COPD和哮喘中观察到的粘液病理过度的有效管理的有用策略。 因此,在本综述中,我们试图概述涉及粘液 - 过度疾病的常规药物疗法,最近的研究结果寻找用于控制肺部粘液的肺精体,旨在揭示潜在的潜在有效的药物治疗 粘液 - 过度症状。

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