...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytokine >Topical application of substance P promotes wound healing in streptozotocin-induced diabetic rats
【24h】

Topical application of substance P promotes wound healing in streptozotocin-induced diabetic rats

机译：P物质的局部应用可促进链脲佐菌素诱导的糖尿病大鼠的伤口愈合

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Substance P (SP) is known to stimulate angiogenesis, fibroblasts proliferation and expressions of cytokines and growth factors involved in wound healing. However, SP level reduces in dermis in diabetics and, hence, it was hypothesized that exogenously applied SP could be helpful in improving wound healing in diabetic rats. Excision skin wound was created on the back of diabetic rats and rats were divided into three groups i.e. (i) saline-, (ii) gel- and (iii) SP-treated. Normal saline, pluronic gel and SP (10-6M) in gel were topically applied once daily for 19days. SP treatment significantly increased the wound closure, levels of interleukin-10, and expressions of vascular endothelial growth factor, transforming growth factor-beta1, heme oxygenase-1 and endothelial nitric oxide synthase, whereas it significantly decreased the expression of tumor necrosis factor-alpha, interleukin-1beta and matrix metalloproteinases-9 in the granulation/healing tissue. The inflammatory cells were present for long time in normal saline-treated group. Histological evaluation revealed better extracellular matrix formation with marked fibroblast proliferation and collagen deposition in SP-treated group. Early epithelial layer formation, increased microvessel density and greater growth associated protein-43 positive nerve fibers were also evidenced in SP-treated group. In conclusion, SP treatment markedly accelerated cutaneous wound healing in diabetic rats.
机译：已知P物质（SP）可刺激血管生成，成纤维细胞增殖以及涉及伤口愈合的细胞因子和生长因子的表达。然而，糖尿病患者的真皮中SP水平降低，因此，假设外源应用SP可能有助于改善糖尿病大鼠的伤口愈合。在糖尿病大鼠的背部形成皮肤皮肤切除伤口，将大鼠分为三组，即（i）盐水处理，（ii）凝胶处理和（iii）SP处理。每天一次将生理盐水，普朗尼克凝胶和凝胶中的SP（10-6M）局部应用一次，持续19天。 SP治疗显着增加伤口闭合，白细胞介素10水平以及血管内皮生长因子，转化生长因子β1，血红素加氧酶-1和内皮型一氧化氮合酶的表达，而显着降低肿瘤坏死因子-α的表达。 ，肉芽/愈合组织中的IL-1β和基质金属蛋白酶9。生理盐水治疗组中炎症细胞长期存在。组织学评估显示，SP治疗组细胞外基质形成更好，成纤维细胞增殖和胶原沉积明显。在SP治疗组中也证实了早期上皮层的形成，微血管密度的增加以及与生长相关的蛋白43阳性神经纤维的生长。总之，SP治疗显着加速了糖尿病大鼠皮肤伤口的愈合。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号