Self-crowding influences the temperature – pressure stability of the human telomere G-quadruplex

J.Somkuti

首页> 外文期刊>Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena >Self-crowding influences the temperature – pressure stability of the human telomere G-quadruplex

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Self-crowding influences the temperature – pressure stability of the human telomere G-quadruplex

机译：自挤影响人体端粒体G-Quadruplex的温度 - 压力稳定性

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We measured the effect of crowded environment on G-quadruplex structures, formed by guanine rich DNA sequences. Fluorescence and infrared spectroscopy were used to determine the temperature stability of G-quadruplex structure formed by the human telomere sequence. We determined the T-p phase diagram of Htel aptamer up to 1?GPa at different self-crowding conditions. The unfolding volume change was determined from the pressure induced shift of the unfolding temperature of the quadruplex form. The unfolding volume change decreased in magnitude, and even its sign changed from negative (?19?ml/mol) to positive (7?ml/mol) under self-crowded conditions. The possible explanations are the appearance of the parallel GQ structure at high concentration or the fact that the volume decrease caused by the released central K+ ion during the unfolding is less significant in crowded environment.

机译：我们测量了鸟嘌呤富含DNA序列形成的G-Quadflex结构对G-Quadflex结构的影响。使用荧光和红外光谱法测定由人端粒序列形成的G-Quadflex结构的温度稳定性。我们确定了HTEL Aptamer的T-P相图，在不同的自挤条件下高达1？GPA。从展开温度的展开温度的压力诱导变化确定展开体积变化。展开体积变化的幅度幅度下降，甚至其标志在自挤条件下从负（Δ19Ωml/ mol）变为正（7？ml / mol）。可能的解释是在高浓度下平行GQ结构的外观，或者在展开期间由释放的中央k +离子引起的体积减小在拥挤环境中的显着较小。

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《Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena》 |2019年第2019期|共1页
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J.Somkuti;
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Department of Biophysics and Radiation Biology Semmelweis University Budapest Hungary;

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正文语种 eng
中图分类生物化学;
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1. Self-crowding influences the temperature – pressure stability of the human telomere G-quadruplex [J] . J.Somkuti Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena . 2019,第期

机译：自挤影响人体端粒体G-Quadruplex的温度 - 压力稳定性
2. Hydration Is a Major Determinant of the G-Quadruplex Stability and Conformation of the Human Telomere 3' Sequence of d(AG_3(TTAG_3)_3) [J] . M. Clarke Miller, Robert Buscaglia, Jonathan B. Chaires, Journal of the American Chemical Society . 2010,第48期

机译：水化作用是d（AG_3（TTAG_3）_3）人端粒3'序列的G-四链体稳定性和构象的主要决定因素。
3. Hydration Is a Major Determinant of the G-Quadruplex Stability and Conformation of the Human Telomere 3′ Sequence of d(AG3(TTAG3)3) [J] . M. Clarke Miller Robert Buscaglia Jonathan B. Chaires Andrew N. Lane and John O. Trent American Chemical Society . 2010,第48期

机译：水合是d（AG3（TTAG3）3）人端粒3'序列的G-四链体稳定性和构象的主要决定因素。
4. The Pattern of Chromosome-Specific Variations in Telomere Length in Humans Shows Signs of Heritability and Is Maintained through Life [C] . J. GRAAKJAER, J.A. LONDONO-VALLEJO, K. CHRISTENSEN, International Association of Biomedical Gerontology International . 2006

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5. Metastability of Tremolite at High Pressures and Temperatures [D] . ?Ott, Jason 2020

机译：高压和温度下透闪石的迁移性
6. High temperatures and human pressures interact to influence mortality in an African carnivore [O] . Daniella Rabaiotti, Rosemary Groom, J. Weldon McNutt, 2021

机译：高温和人类压力互动影响非洲食肉动物的死亡率
7. Influence of pH, temperature and the cationic porphyrin TMPyP4 on the stability of the i-motif formed by the 5′-(C3TA2)4-3′ sequence of the human telomere [O] . Fernández, Sergio, Eritja Casadellà, Ramón, Aviñó, Anna, 2011

机译：pH，温度和阳离子卟啉TMPyP4对人端粒5'-（C3TA2）4-3'序列形成的i-基序稳定性的影响

Self-crowding influences the temperature – pressure stability of the human telomere G-quadruplex

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