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Next Chapter of the Taiwan Biobank: Sustainability and Perspectives

机译：下一章台湾Biobank：可持续性和观点

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The emergence of biobanks has expanded the scope of biomedical research, ushering in an era of "precision medicine" to improve the treatment of disease. However, biobanks also face sustainability challenges comprising three dimensions-"financial," "operational," and "social." The Taiwan Biobank (TWB), as a large-scale national biobank that supplies valuable phenotypic and genetic information to biomedical researchers on an application basis to investigate the relationship among personal health, genes, lifestyle, environment and diseases of the Taiwanese population, has not been sufficiently explored by researchers. Although the TWB has successfully reached a few milestones since its inception, it faces many sustainability challenges. For the next chapter of the TWB, we propose three strategies to improve sustainability. First, the Ministry of Health and Welfare launched the TWB as an infrastructure project under the leadership of Academia Sinica in 2012. We now believe that it is time that the TWB is transformed into a legal entity as a nondepartmental public body. This would not only ensure efficient, effective, and flexible operation, but would also facilitate cooperation with commercial entities. Second, we suggest that the TWB integrates with other Taiwanese biobanks to reduce cost, improve low utilization, and expand specimen collection. Third, self-financing is important if funding is ceased. Besides implementing a cost-recovery model, the commodities developed by the TWB (e.g., TWB 2.0 microarray) will help increase income. After each of these strategies has been discussed in detail, this article will conclude by highlighting how these practices can help improve biobank sustainability.
机译：BioBanks的出现扩大了生物医学研究的范围，迎来了“精密药物”时代来改善疾病的治疗。然而，Biobanks也面临着包括三维的可持续发展挑战 - “财务”，“运作”和“社会”。台湾Biobank（TWB）是一个大型国家BIOBANK，向生物医学研究人员提供有价值的表型和遗传信息，以申请基础来调查台湾人口的个人健康，基因，生活方式，环境和疾病之间的关系，并没有被研究人员充分探索。虽然TWB成立以来成功达到了一些里程碑，但它面临着许多可持续发展挑战。对于TWB的下一章，我们提出了三个改善可持续性的战略。首先，卫生部和福利部在2012年在中国学术界的领导下推出了TWB作为基础设施项目。我们现在认为，这是TWB作为一个非洲公共机构转变为合法实体的时候了。这不仅可以确保高效，有效和灵活的运行，而且还可以促进与商业实体的合作。其次，我们建议TWB与其他台湾生物人数集成，以降低成本，提高利用率，并展开标本收集。第三，如果停止资金，自筹资金很重要。除了实施成本恢复模型外，由TWB（例如，TWB 2.0微阵列）开发的商品将有助于增加收入。在详细讨论了这些策略中，本文将突出这些实践如何有助于提高BioBank可持续性。

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