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The Importance of Human Tissue Bioresources in Advancing Biomedical Research

机译：人体组织生物资源在推进生物医学研究中的重要性

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Medical research advances enabling the realization of precision medicine have relied heavily on the biospecimens provided by bioresources to identify the targets and biomarkers that are the focus of the new generation of more effective molecular-based therapies for specific subtypes of diseases. Through the biospecimens they have distributed, bioresources have permitted subtypes of cancers to be identified and molecular features of these subtypes to be effectively targeted. A prototype example is the human epidermal growth factor receptor type 2 (HER2), which currently is targeted in breast and gastric cancers. In the future, the use of biospecimens from bioresources will continue to increase the understanding of the molecular actions of drugs and how drugs may be more or less active in subpopulations of patients. Although the biospecimen inventories of the initial forms of bioresources may not have always been optimally planned and, therefore, utilized in supporting biomedical research, bioresources are evolving and overall, bioresource inventories and increasingly their prospective collection capabilities will continue to be a critical component of the research infrastructure.
机译：能够实现精密药物的医学研究促进依赖于生物资源提供的生物开发，以确定目标和生物标志物，这些目标和生物标志物是对特定疾病亚型的新一代基于分子的疗法的重点。通过它们分布的生物开发，源自探测癌的亚型和这些亚型的分子特征将有效地靶向。原型例是人表皮生长因子受体类型2（HER2），其目前靶向乳腺和胃癌。将来，从生物资源中使用生物起源将继续增加对药物的分子作用以及药物在患者的亚群中可能会有更多或更少的活性药物的理解。虽然初始形式的生物资料的生物中的库存可能始终是最佳的计划，但是，利用支持生物医学研究，流化源正在发展，整体，生物资源库存和越来越多的预期收集能力将继续成为一个关键的组成部分研究基础设施。

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