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首页> 外文期刊>Biophysical reviews and letters >Interplay Among Constitutes of Ebola Virus: Nucleoprotein, Polymerase L, Viral Proteins
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Interplay Among Constitutes of Ebola Virus: Nucleoprotein, Polymerase L, Viral Proteins

机译：埃博拉病毒构成之间的相互作用：核蛋白，聚合酶L，病毒蛋白

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摘要

Ebola virus is a highly lethal filovirus, claimed thousands of people in its recent outbreak. Seven viral proteins constitute ebola viral structure, and four of them (nucleoprotein (NP), polymerase L, VP35 and VP30) participate majorly in viral replication and transcription. We have elucidated a conformation change of NP cleft by VP35 NP-binding protein domains through superimposing two experimental NP structure images and discussed the function of this conformation change in the replication and transcription with polymerase complex (L, VP35 and VP30). The important roles of VP30 in viral RNA synthesis have also been discussed. A “tapping” model has been proposed in this paper for a better understanding of the interplay among the four viral proteins (NP, polymerase L, VP35 and VP30). Moreover, we have pinpointed some key residue changes on NP (both NP N- and C-terminal) and L between Reston and Zaire by computational studies. Together, this paper provides a description of interactions among ebola viral proteins (NP, L, VP35, VP30 and VP40) in viral replication and transcription, and sheds light on the complex system of viral reproduction.
机译：埃博拉病毒是一种高度致命的血清病毒，在最近爆发了成千上万的人。七种病毒蛋白构成埃博拉病毒结构，其中四种（核蛋白（NP），聚合酶L，VP35和VP30）主要参与病毒复制和转录。通过叠加两个实验NP结构图像，阐明了VP35 NP结合蛋白结构域的NP裂缝的构象变化，并讨论了与聚合酶复合物（L，VP35和VP30）的复制和转录中该构象变化的功能。还讨论了VP30在病毒RNA合成中的重要作用。本文提出了“攻丝”模型，以更好地了解四种病毒蛋白（NP，聚合酶L，VP35和VP30）之间的相互作用。此外，通过计算研究，我们已经精确地对NP（NP N和C末端）和L之间的一些关键残留物变化和L。本文在一起，提供了埃博拉病毒蛋白（NP，L，VP35，VP30和VP30）在病毒复制和转录中的相互作用的描述，并在虚拟病毒繁殖系统上脱光。

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  • 来源
    《Biophysical reviews and letters》 |2017年第3期|共24页
  • 作者

    Minchuan Zhang; Peiming He; Jing Su; Dadabhai T. Singh; Hailei Su; Haibin Su;

  • 作者单位

    *Institute of Advanced Studies Nanyang Technological University 60 Nanyang View Singapore 639673 Singapore;

    *Institute of Advanced Studies Nanyang Technological University 60 Nanyang View Singapore 639673 Singapore;

    *Institute of Advanced Studies Nanyang Technological University 60 Nanyang View Singapore 639673 Singapore;

    *Institute of Advanced Studies Nanyang Technological University 60 Nanyang View Singapore 639673 Singapore;

    ?Bengbu Hospital of Traditional Chinese Medicine 4339 Huai-shang Road Bengbu Anhui 233080 P. R. China;

    *Institute of Advanced Studies Nanyang Technological University 60 Nanyang View Singapore 639673 Singapore;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物物理学;
  • 关键词

    Ebola; nucleoprotein (NP); viral proteins; comparison; Reston; Zaire;

    机译：埃博拉;核蛋白（NP）;病毒蛋白;比较;reaston;扎伊尔;

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