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首页> 外文期刊>Cytokine >Leukaemia inhibitory factor and interleukin 6 inhibit secretion of prolactin and growth hormone by rat pituitary mtt/sm cells.
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Leukaemia inhibitory factor and interleukin 6 inhibit secretion of prolactin and growth hormone by rat pituitary mtt/sm cells.

机译：白血病抑制因子和白介素6抑制大鼠垂体mtt / sm细胞分泌催乳激素和生长激素。

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摘要

The rat pituitary cell line, MtT/SM, has the characteristics of somatomammotrophs. The cells secrete both prolactin (PRL) and growth hormone (GH). We examined the effects of cytokines such as leukaemia inhibitory factor (LIF), interleukin 6 (IL-6), oncostatin M and interleukin 11 on the secretion of these hormones by the cells. These cytokines stimulate proliferation of the cells and inhibit the secretion of PRL by 70-80% and that of GH by 50%. They induce tyrosine phosphorylation of STAT3 in the cells. The cells containing PRL or GH decreased at 48 h after treatment of the cells with LIF or IL-6. These results suggest that the LIF/IL-6 family of cytokines inhibits the functions of mammotrophs and somatotrophs in the pituitary gland. Copyright 2001 Academic Press.
机译：大鼠垂体细胞系MtT / SM具有体细胞营养缺陷型的特征。这些细胞同时分泌催乳激素（PRL）和生长激素（GH）。我们检查了诸如白血病抑制因子（LIF），白介素6（IL-6），制瘤素M和白介素11等细胞因子对细胞分泌这些激素的影响。这些细胞因子刺激细胞增殖，抑制PRL分泌70-80％，抑制GH分泌50％。它们在细胞中诱导STAT3的酪氨酸磷酸化。用LIF或IL-6处理后48小时，含有PRL或GH的细胞减少。这些结果表明，LIF / IL-6细胞因子家族抑制垂体中的哺乳类和体养类动物的功能。版权所有2001，学术出版社。

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