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首页> 外文期刊>Biomedicine & pharmacotherapy =: Biomedecine & pharmacotherapie >Effects of separate and concurrent supplementation of Nano-sized clinoptilolite and Nigella sativa on oxidative stress, anti-oxidative parameters and body weight in rats with type 2 diabetes
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Effects of separate and concurrent supplementation of Nano-sized clinoptilolite and Nigella sativa on oxidative stress, anti-oxidative parameters and body weight in rats with type 2 diabetes

机译：纳米尺寸Clinophtilolite和Nigella Sativa对2型糖尿病大鼠氧化应激，抗氧化参数和体重的影响

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Abstract Objectives The objective of this study was to investigate the effects of separate and concurrent supplementation of natural nano-sized clinoptilolite (NCLN) and Nigella sativa (NS) on oxidative stress (OS), anti-oxidative parameters and body weight (BW) in high-fat-diet (HFD)/streptozotocin (STZ)-induced diabetic rats. Methods In this experimental study, 42 male Wistar rats were divided into diabetic (n=36) and non-diabetic (n=6) groups. The diabetic group (DG) was fed with a HFD for one month, then injected with intra-peritoneal single dose STZ (35?mg/kg BW). The DG was divided into 4 subgroups: [1] control (DC), [2] NS 1%/food, [3] NCLN 2%/food, [4] NS 1%/food?+?NCLN 2%/food. At the end of the 7th week, malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPX) levels and total antioxidant capacity (TAC) were measured. Results The MDA level was decreased in the NCLN ( p ?=?0.011) and NCLN+NS ( p ?=?0.007) groups compared to the DC group. The GPX level increased in the NS and NCLN groups compared to the DC group ( p ?=?0.014 and p ?=?0.034). In addition, the level of TAC demonstrated increase in the untreated DG and NS groups, as compared to the normal control (NC) group ( p DC ?=?0.031 and p NS ?=?0.024). Moreover, in the NS+NCLN group, the level of SOD decreased in comparison to the NS and NCLN groups ( p ? Conclusions According to results, separate supplementation of NS and NCLN was more beneficent on anti-oxidative parameters than concurrent supplementation of NS and NCLN.
机译：摘要目的本研究的目的是研究自然纳米尺寸的临床（NCLN）和NIGELLA Sativa（NS）对氧化应激（OS），抗氧化参数和体重（BW）的影响的影响高脂饮食（HFD）/链脲佐菌素（STZ）诱导糖尿病大鼠。方法在该实验研究中，将42只雄性Wistar大鼠分为糖尿病（n = 36）和非糖尿病（n = 6）基团。将糖尿病群（DG）用HFD喂养一个月，然后用腹膜内单剂量STZ（35μmΩ/ kg bw）注射。将DG分为4个子组：[1]对照（DC），[2] NS 1％/食物，[3] NCLN 2％/食物，[4] NS 1％/食物？+？NCLN 2％/食物。在第7周结束时，测定丙二醛（MDA），超氧化物歧化酶（SOD），谷胱甘肽过氧化物酶（GPX）水平和总抗氧化能力（TAC）。结果与DC组相比，NCLN（P？= 0.011）和NCLN + NS（P？= 0.007）组中的MDA水平降低。与DC组相比，NS和NCLN组的GPX水平增加（P？= 0.014和P？= 0.034）。此外，与正常对照（NC）组相比此外，在NS + NCLN组中，与NS和NCLN组相比，SOD水平降低（P？根据结果的结论，单独补充NS和NCLN对抗氧化参数比NS和NS的并发补充更具益智ncln。

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