首页> 外文期刊>Journal of Molecular Biology Research >Synergistic Effects of Nano-Sized Clinoptilolite and Nigella Sativa on Inflammatory and Hematological Factors in Rats with Type 2 Diabetes
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Synergistic Effects of Nano-Sized Clinoptilolite and Nigella Sativa on Inflammatory and Hematological Factors in Rats with Type 2 Diabetes

机译:纳米斜发沸石和黑叶苜蓿对2型糖尿病大鼠炎症和血液学因素的协同作用

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The inflammatory efficacy of supplementation of natural nano-sized clinoptilolite (NCLN) and Nigella sativa (NS) was evaluated At the end of 7th week in interleukin1 (IL1), interleukin10 (IL-10), interleukin6 (IL-6) and platelet (PLT), white blood cell (WBC), red blood cell (RBC), hemoglobin (HGB), hematocrit (HCT), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV). 42 rats were divided into two groups as diabetic and non-diabetic. Diabetic group divided into 4 subgroups as normal control (NC), NS 1% food, NCLN 2%/food, NS 1%/food + NCLN 2%/food and fed high fat diet (HFD) for 1 month, then injected 35mg/kg BW STZ to induce type 2 diabetes (T2D). Our results showed IL-10 in NCLN and NCLN+NS groups were significantly higher NC group (p<0.05). IL-6 decreased in NS group in comparison with DC group. And PLT decreased significantly in NCLN group in comparison with other groups. Our data suggests NS and NCLN may have synergistic beneficial effects on increasing some of anti-inflammatory factors.
机译:在第7周末评估了补充天然纳米斜发沸石(NCLN)和苜蓿(Nigella sativa)(NS)在白细胞介素1(IL1),白细胞介素10(IL-10),白细胞介素6(IL-6)和血小板( PLT),白细胞(WBC),红细胞(RBC),血红蛋白(HGB),血细胞比容(HCT),平均红细胞血红蛋白(MCH),平均红细胞血红蛋白浓度(MCHC),平均红细胞体积(MCV)。将42只大鼠分为糖尿病和非糖尿病两组。糖尿病组分为4个亚组,分别为正常对照组(NC),NS 1%食品,NCLN 2%/食品,NS 1%/食品+ NCLN 2%/食品,并喂养高脂饮食(HFD)1个月,然后注射35mg / kg BW STZ诱发2型糖尿病(T2D)。我们的结果显示,NCLN和NCLN + NS组中的IL-10显着高于NC组(p <0.05)。 NS组IL-6水平较DC组降低。 NCLN组与其他组相比,PLT显着降低。我们的数据表明NS和NCLN可能对增加某些抗炎因子具有协同有益的作用。

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