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首页> 外文期刊>Cytokine >Interleukin-10 or tumor necrosis factor-alpha polymorphisms and the natural course of hepatitis C virus infection in a hyperendemic area of Japan.
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Interleukin-10 or tumor necrosis factor-alpha polymorphisms and the natural course of hepatitis C virus infection in a hyperendemic area of Japan.

机译：白细胞介素10或肿瘤坏死因子-α多态性与日本高流行地区丙型肝炎病毒感染的自然过程。

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摘要

We investigated the effects of polymorphisms in interleukin (IL)-10 and tumor necrosis factor (TNF)-alpha on the natural course of hepatitis C virus (HCV) infection in a community-based population in Japan. A total of 460 anti-HCV antibody seropositive individuals were classified into two groups, those who were positive or negative for HCV RNA. In HCV RNA-positive individuals with at least four annual alanine aminotransferase (ALT) measurements taken between 1993 and 2003, 74 exhibited persistently normal ALT levels, while 211 had one or more elevated ALT level tests. We examined the relationships between polymorphisms in the genes encoding IL-10 (-1082, -819, -592) or TNF-alpha (-308, -238) and HCV clearance, ALT abnormalities, or serum level of type IV collagen 7S, a marker of hepatic fibrosis. These polymorphisms were equally distributed among the patient subgroups with differential HCV RNA clearances or ALT abnormalities. Serum levels of type IV collagen 7S, however, were significantly higher in individuals with an A at position -238 or -308 in the TNF-alpha gene promoter than in individuals lacking these polymorphisms. We conclude that, while the relationships between inherited variations in IL-10 or TNF-alpha expression are not associated with alterations in HCV clearance or ALT levels, TNF-alpha polymorphisms may be associated with hepatic fibrosis.
机译：我们调查了日本社区居民中白介素（IL）-10和肿瘤坏死因子（TNF）-α的多态性对丙型肝炎病毒（HCV）感染自然过程的影响。将总共​​460名抗HCV抗体血清阳性的人分为两组，即HCV RNA阳性或阴性的人。在1993年至2003年之间进行至少四次年度丙氨酸氨基转移酶（ALT）年度检测的HCV RNA阳性个体中，有74例表现出持续正常的ALT水平，而211例进行了一项或多项ALT升高测试。我们检查了编码IL-10（-1082，-819，-592）或TNF-alpha（-308，-238）的基因中的多态性与HCV清除率，ALT异常或IV型胶原7S血清水平之间的关系，肝纤维化的标志物。这些多态性在具有不同HCV RNA清除率或ALT异常的患者亚组中平均分布。但是，在TNF-alpha基因启动子的-238或-308位具有A的个体中，IV型胶原7S的血清水平明显高于缺乏这些多态性的个体。我们得出的结论是，尽管IL-10或TNF-α表达的遗传变异之间的关系与HCV清除率或ALT水平的改变无关，但TNF-α多态性可能与肝纤维化有关。

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