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首页> 外文期刊>Cytokine >Cytokine profiles of HIV patients with pulmonary tuberculosis resulting from adjunct immunotherapy with herbal phytoconcentrates Dzherelo and Anemin.
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Cytokine profiles of HIV patients with pulmonary tuberculosis resulting from adjunct immunotherapy with herbal phytoconcentrates Dzherelo and Anemin.

机译：草药植物浓缩物Dzherelo和Anemin的辅助免疫疗法导致的HIV肺结核患者的细胞因子谱。

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Dzherelo (Immunoxel) and Anemin when combined with standard anti-tuberculosis therapy (ATT) were shown to produce better clinical outcome than chemotherapy alone. Sixty HIV-positive patients with active pulmonary TB were equally divided into three matched groups to receive either ATT, ATT+Dzherelo, or ATT+Dzherelo+Anemin. Peripheral blood samples were measured by ELISA for plasma levels of IL-2, IL-6, TNF-alpha, IFN-gamma, and IFN-alpha. After 6 months of follow-up Dzherelo and Dzherelo+Anemin combinations produced 61% (P=0.005) and 44.4% (P=0.06) higher levels of IL-2, whereas in ATT group they were reduced by 33.1% (P=0.002). The levels of IL-6 increased by 17% (P=0.15) in ATT group, but declined in both immune intervention groups by 26.2% (P=0.007) and 21.3% (P=0.22). TNF-alpha was suppressed in two immunotherapy groups by 19.1% (P=0.06) and 76.3% (P=0.02), respectively, but had risen by 14% (P=0.42) in ATT patients. The pattern of production of IFN-gamma was opposite to that of TNF-alpha, but statistical significance was stronger in patients receiving ATT and Dzherelo+Anemin than in Dzherelo group: -34% (P=0.004), +31.9% (P=0.008), and +17.3% (P=0.33), respectively. Moderately decreased levels of IFN-alpha were observed in all treatment arms (range 0.9-16.6%) but differences were not significant. Despite considerable intra-group variation in cytokine production, the baseline inter-group averages were not statistically different indicating that the results were not biased by sample heterogeneity. Immunomodulators used in this study possibly act by enhancing natural immune response against TB. Expanded study of other cytokines and correlates relevant to control and protection from TB and HIV is needed in order to identify biomarkers of favorable treatment outcome, which may aid design of better immune interventions and vaccines.
机译：Dzherelo（Immunoxel）和Anemin与标准抗结核治疗（ATT）结合使用比单独化疗产生更好的临床效果。将60例活动肺结核的HIV阳性患者平均分为三组，分别接受ATT，ATT + Dzherelo或ATT + Dzherelo + Anemin。通过ELISA测量外周血样品的IL-2，IL-6，TNF-α，IFN-γ和IFN-α的血浆水平。经过6个月的随访，Dzherelo和Dzherelo + Anemin组合产生的IL-2水平升高了61％（P = 0.005）和44.4％（P = 0.06），而ATT组则​​降低了33.1％（P = 0.002） ）。 ATT组的IL-6水平增加了17％（P = 0.15），但两个免疫干预组的IL-6水平均下降了26.2％（P = 0.007）和21.3％（P = 0.22）。在两个免疫治疗组中，TNF-α分别被抑制了19.1％（P = 0.06）和76.3％（P = 0.02），但在ATT患者中却上升了14％（P = 0.42）。 IFN-γ的产生方式与TNF-α相反，但接受ATT和Dzherelo + Anemin的患者的统计学意义比Dzherelo组更强：-34％（P = 0.004），+ 31.9％（P = 0.008）和+ 17.3％（P = 0.33）。在所有治疗组中均观察到中等程度的IFN-α水平降低（范围为0.9-16.6％），但差异不显着。尽管细胞因子产生的组内差异很大，但基线组间平均值在统计学上没有差异，表明结果不受样品异质性的影响。这项研究中使用的免疫调节剂可能通过增强针对结核病的天然免疫反应发挥作用。为了鉴定具有良好治疗效果的生物标志物，可能需要对其他细胞因子及其相关的控制和保护相关的结核病进行广泛的研究，这可能有助于设计更好的免疫干预措施和疫苗。

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