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首页> 外文期刊>Cytokine >The Th17/Treg functional imbalance during atherogenesis in ApoE(-/-) mice.
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The Th17/Treg functional imbalance during atherogenesis in ApoE(-/-) mice.

机译：在ApoE（-/-）小鼠动脉粥样硬化过程中Th17 / Treg功能失衡。

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OBJECTIVE: Atherosclerosis is a chronic inflammatory disease regulated by T lymphocyte subsets. Recently, CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cells and Th17 cells have been described as two distinct subsets and have the opposite effects on autoimmunity. Clinical observation has revealed that the Th17/Treg imbalance exists in patients with acute coronary syndrome. We investigated whether the Th17/Treg functional imbalance existed during atherogenesis in ApoE(-/-) mice. METHODS AND RESULTS: Th17/Treg functions at different levels including cell frequencies, related cytokine secretion and key transcription factors were investigated comparatively between ApoE(-/-) mice and their age-matched C57BL/6J mice. The results demonstrated that ApoE(-/-) mice revealed significantly increased secretion of Th17 related cytokines (IL-17 and IL-6) and expression of transcription factor (RORgammat) levels and obviously decreased number in Treg cells, secretion of Treg related cytokines (TGF-beta(1)) and expression of transcription factor (Foxp3) levels as compared with age-matched C57BL/6J mice. Th17 related mediators reached their maximum expression values at the early stage (8-16weeks of age) in ApoE(-/-) mice, and then followed by continuous depression of their expression levels. Meanwhile, the expression of Treg related mediators was much lower in ApoE(-/-) mice than in their age-matched wild-type littermates. CONCLUSIONS: Th17/Treg functional imbalance exists during atherogenesis in ApoE(-/-) mice, suggesting a potential role of Th17/Treg imbalance in the formation and progression of atherosclerosis.
机译：目的：动脉粥样硬化是一种由T淋巴细胞亚群调节的慢性炎症性疾病。最近，CD4（+）CD25（+）Foxp3（+）调节性T（Treg）细胞和Th17细胞已被描述为两个不同的亚型，并且对自身免疫具有相反的作用。临床观察表明，急性冠脉综合征患者存在Th17 / Treg失衡。我们调查在ApoE（-/-）小鼠动脉粥样硬化发生过程中是否存在Th17 / Treg功能失衡。方法和结果：在ApoE（-/-）小鼠和年龄匹配的C57BL / 6J小鼠之间比较研究了Th17 / Treg在不同水平的功能，包括细胞频率，相关的细胞因子分泌和关键转录因子。结果表明，ApoE（-/-）小鼠显示Th17相关细胞因子（IL-17和IL-6）的分泌显着增加，并且转录因子（RORgammat）的表达水平明显升高，Treg细胞中的数量明显减少，Treg相关细胞因子的分泌（TGF-beta（1））和转录因子（Foxp3）的表达水平与年龄匹配的C57BL / 6J小鼠相比。 Th17相关介体在ApoE（-/-）小鼠的早期（8-16周龄）达到其最大表达值，然后连续降低其表达水平。同时，在ApoE（-/-）小鼠中，Treg相关介质的表达比其年龄匹配的野生型同窝小鼠低得多。结论：ApoE（-/-）小鼠动脉粥样硬化过程中存在Th17 / Treg功能失衡，提示Th17 / Treg不平衡在动脉粥样硬化的形成和发展中具有潜在作用。

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