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首页> 外文期刊>Cytokine >The change of cytokines in tear and blood after different pterygium operation.
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The change of cytokines in tear and blood after different pterygium operation.

机译：不同翼状operation肉手术后眼泪和血液中细胞因子的变化。

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摘要

Pterygium is an invasion of altered ocular tissue into the cornea. Bone marrow-derived stem cells have been reported to be involved in wound healing under chemotactic factors after pterygium removal and pain may act as a trigger signal. We evaluated the change of systemic and local chemotactic factors that could affect the mobilization and migration of BMSCs to the wound bed after conventional bare sclera pterygium excision. We also applied temporary amniotic membrane patch after pterygium removal, and compared the changes of cytokines with those of conventional bare sclera excision group. Substance-P (SP), vascular endothelial growth factor (VEGF), and stem cell factor (SCF) were measured in plasma and tear using ELISA and migrating CD34(+) cells by flow cytometry. The results showed that post-operative pain was much reduced (p<0.05), and SP, VEGF and SCF kept consistently lower levels in plasma after temporary amniotic membrane application. Circulating CD34(+) cells increased slightly in the temporary amniotic membrane patch group compared with marked increase in the bare sclera group. Thus, the application of a temporary amniotic membrane after pterygium removal might be an effective therapeutic means by controlling pain and excessive infiltration of bone marrow-derived stem cells.
机译：翼状is肉是眼组织的改变侵入角膜。据报道，在去除翼状g肉后，骨髓来源的干细胞在趋化因子的作用下参与了伤口的愈合，疼痛可能是触发信号。我们评估了全身和局部趋化因子的变化，这些变化可能会影响常规裸露巩膜翼状exc肉切除术后BMSC的动员和迁移。我们还应用了去除翼状g肉后的临时羊膜贴片，并将细胞因子的变化与常规裸巩膜切除组的细胞因子的变化进行了比较。使用ELISA测定血浆和泪液中的P物质（SP），血管内皮生长因子（VEGF）和干细胞因子（SCF），并通过流式细胞术迁移CD34（+）细胞。结果表明，应用临时羊膜后，术后疼痛明显减轻（p <0.05），并且SP，VEGF和SCF始终保持较低的血浆水平。相比于裸露巩膜组明显增加，临时羊膜贴片组中的循环CD34（+）细胞略有增加。因此，去除翼状ery肉后应用临时羊膜可能是控制疼痛和骨髓干细胞过度浸润的有效治疗手段。

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