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首页> 外文期刊>BJOG: an international journal of obstetrics and gynaecology >Different and diverse anaerobic microbiota were seen in women living with HIV HIV with unsuppressed HIV HIV viral load and in women with recurrent bacterial vaginosis: a cohort study
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Different and diverse anaerobic microbiota were seen in women living with HIV HIV with unsuppressed HIV HIV viral load and in women with recurrent bacterial vaginosis: a cohort study

机译：在患有艾滋病毒艾滋病毒艾滋病毒艾滋病毒艾滋病毒病毒病毒负荷和经常性细菌阴道病的妇女患有艾滋病毒艾滋病毒的妇女中看到不同和多样化的厌氧微生物群：队列研究

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Objective To compare the vaginal microbiota of women living with HIV ( WLWH ) with the vaginal microbiota of women with recurrent bacterial vaginosis ( BV ) and healthy women without HIV to determine if there are differences in the vaginal microbiome, what factors influence these differences, and to characterise HIV clinical parameters including viral load and CD 4 count in relation to the vaginal microbiome. Design Observational cohort study. Setting Canada. Population Women aged 18–49?years who were premenopausal and not pregnant were recruited into three cohorts: healthy women, WLWH and women with recurrent BV . Methods Demographic and clinical data were collected via interviews and medical chart reviews. Vaginal swabs were collected for Gram‐stain assessment and microbiome profiling using the cpn 60 barcode sequence. Main outcome measures To compare overall community composition differences, we used compositional data analysis methods, hierarchical clustering and Kruskal–Wallis tests where appropriate. Results Clinical markers such as odour and abnormal discharge, but not irritation, were associated with higher microbial diversity. WLWH with unsuppressed HIV viral loads were more likely than other groups to have non‐ Gardnerella ‐dominated microbiomes. HIV was associated with higher vaginal microbial diversity and this was related to HIV viral load, with unsuppressed women demonstrating significantly higher relative abundance of Megasphaera genomosp. 1, Atopobium vaginae and Clostridiales sp. (all P ??0.05) compared with all other groups. Conclusions In WLWH , unsuppressed HIV viral loads were associated with a distinct dysbiotic profile consisting of very low levels of Lactobacillus and high levels of anaerobes. Tweetable abstract Vaginal microbiomes in WLWH with viral load 50?copies/ml have distinct dysbiotic profiles with high levels of anaerobes.
机译：目的，将患有艾滋病毒（WLWH）的阴道微生物群与具有复发性细菌性阴道病（BV）和健康女性的阴道微生物，无需艾滋病毒，以确定阴道微生物组中是否存在差异，这是影响这些差异的因素表征艾滋病毒临床参数，包括病毒载荷和CD 4关于阴道微生物组的计数。设计观察队列研究。设置加拿大。 18-49岁的人口妇女？曾经招聘过孕妇，并未怀孕招募到三个队列：健康的女性，WLWH和经常性BV的妇女。方法通过访谈和医疗图表收集人口统计和临床资料。使用CPN 60条形码序列收集用于革兰氏染色评估和微生物组分布的阴道拭子。主要的结果措施来比较整体社区构成差异，我们使用了适当的组成数据分析方法，分层聚类和Kruskal-Wallis测试。结果临床标记如气味和异常放电，但不刺激，与更高的微生物多样性相关。 WLWH与未抑制的艾滋病毒病毒载体更可能与其他基团具有非GARDNELLEALLA族微生物酶。艾滋病毒与较高的阴道微生物多样性有关，这与艾滋病毒病毒载量有关，无抑制的妇女展示了巨大的巨型大量的相对丰富。 1，含缺口和梭菌。 （所有p？＆＆ 0.05）与所有其他组相比。结论在WLWH中，未抑制的艾滋病毒病毒载体与具有极低水平的乳杆菌和高水平的厌氧物组成的不同的歧视性曲线相关。 WLWH与病毒载荷＆ 50℃/ ml具有高水平的厌氧物的不同性卵泡谱的促抽象阴道微生物。

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