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首页> 外文期刊>Cytokine >Cytokine profiles of seventeen cytokines, growth factors and chemokines in cord blood and its relation to perinatal clinical findings.
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Cytokine profiles of seventeen cytokines, growth factors and chemokines in cord blood and its relation to perinatal clinical findings.

机译:脐带血中十七种细胞因子,生长因子和趋化因子的细胞因子谱及其与围生期临床表现的关系。

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Few papers have investigated the cytokine profiles of multiple cytokines in cord blood. We obtained cord blood samples from 224 infants admitted to our neonatal intensive care unit. Cytokine profiles of 17 cytokines were investigated using cytometric bead array technology. We found a wide variety of cytokines of various levels which ranged from 0.59pg/ml (in Interleukin (IL)-4) to 222.0pg/ml (in macrophage inflammatory protein-1beta. Pro-inflammatory cytokines were highly correlated with each other and with granulocyte-colony stimulating factor and IL-8. On the contrary, IL-5, IL-13, and IL-17 did not show any significant correlation with other cytokines. Several maternal factors were strongly related to several cytokines in cord blood. IL-6, IL-8 and monocyte chemotactic protein-1 were closely related to certain neonatal diseases in preterm neonates. Some cytokines may be regulated independently of each other, while others appear to work as a network affecting physiological and pathological conditions in the fetus.
机译:很少有论文研究脐带血中多种细胞因子的细胞因子谱。我们从入院新生儿重症监护室的224名婴儿中获得了脐血样本。使用细胞计数微珠阵列技术研究了17种细胞因子的细胞因子谱。我们发现了各种不同水平的细胞因子,范围从0.59pg / ml(在白介素(IL)-4中)到222.0pg / ml(在巨噬细胞炎性蛋白1beta中)。促炎性细胞因子彼此之间高度相关,并且IL-5,IL-13和IL-17与其他细胞因子没有明显的相关性,而一些母体因子与脐带血中的几种细胞因子密切相关。 IL-6,IL-8和单核细胞趋化蛋白-1与早产儿的某些新生儿疾病密切相关,某些细胞因子可能彼此独立调节,而另一些似乎起着影响胎儿生理和病理状况的作用。 。

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