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首页> 外文期刊>Cytokine >Soluble IL-1RII and IL-18 are associated with incipient upper extremity soft tissue disorders.
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Soluble IL-1RII and IL-18 are associated with incipient upper extremity soft tissue disorders.

机译：可溶性IL-1RII和IL-18与早期上肢软组织疾病有关。

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Previous studies suggest a role for IL-1beta in the pathophysiology of upper extremity soft tissue disorders (UESTDs). We studied the levels of interleukin-1 family members in patients with incipient UESTDs and compared them with healthy controls. In this case control study, we included 163 patients with UESTDs and symptom duration shorter than 1 month and 42 healthy controls matched for age and gender at the group level. Serum levels of cytokines IL-1alpha, IL-1beta, IL-1Ra, IL-6, IL-8, IL-18, IL-33, TNFalpha and sensitized C-reactive protein as well as IL-1 family soluble receptors sIL-1RII and sST2 were assessed. We used unconditional logistic regression models to study the associations between cytokines and UESTDs. After adjustment for potential confounders, the serum levels of sIL-1RII (p<0.001) and sST2 (p=0.014) were higher in the patients than the controls. The level of IL-18 was lower in the patients than the controls (p=0.005). There were no significant differences between the patients and controls regarding the levels of IL-1alpha, IL-1beta, IL-1Ra, IL-33, IL-6, IL-8, TNFalpha, or sensitized C-reactive protein. The levels of circulating sIL-1RII and IL-18 are associated with incipient UESTDs, suggesting an important role for these IL-1 family members in the early course of UESTDs.
机译：先前的研究表明IL-1beta在上肢软组织疾病（UESTDs）的病理生理学中的作用。我们研究了初发UESTD患者的白细胞介素1家庭成员的水平，并将其与健康对照进行比较。在本病例对照研究中，我们纳入了163名UESTDs和症状持续时间少于1个月的患者，以及42名年龄和性别相匹配的健康对照组。血清细胞因子IL-1alpha，IL-1beta，IL-1Ra，IL-6，IL-8，IL-18，IL-33，TNFalpha和致敏的C反应蛋白以及IL-1家族可溶性受体sIL-评估了1RII和sST2。我们使用无条件逻辑回归模型来研究细胞因子与UESTD之间的关联。调整潜在混杂因素后，患者的sIL-1RII（p <0.001）和sST2（p = 0.014）的血清水平高于对照组。患者中的IL-18水平低于对照组（p = 0.005）。患者和对照组之间在IL-1alpha，IL-1beta，IL-1Ra，IL-33，IL-6，IL-8，TNFalpha或致敏的C反应蛋白水平上没有显着差异。循环中的sIL-1RII和IL-18的水平与早期的UESTD相关，表明这些IL-1家族成员在UESTD的早期过程中起着重要的作用。

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