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首页> 外文期刊>Cytokine >The association between common genetic variant of microRNA-146a and cancer susceptibility.
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The association between common genetic variant of microRNA-146a and cancer susceptibility.

机译：microRNA-146a常见遗传变异与癌症易感性之间的关联。

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Published data on the association between microRNA-146a (miR-146a) G/C polymorphism and cancer susceptibility are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 23 studies including 10,585 cases and 12,183 controls were used in the meta-analysis. Overall, no significant associations were found between miR-146a G/C polymorphism and cancer risk when all studies pooled into the meta-analysis (GC vs. CC: OR=1.08, 95% CI=0.94-1.24; GG vs. CC: OR=1.13, 95% CI=0.93-1.37; dominant model: OR=1.09, 95% CI=0.94-1.26). In the subgroup analysis by ethnicity, still no significant associations were found. In the subgroup analysis by cancer type, statistically significantly increased risks were found for papillary thyroid carcinoma (GC vs. CC: OR=3.44, 95% CI=1.86-6.34; GG vs. CC: OR=2.20, 95% CI=1.22-3.99; dominant model: OR=2.68, 95% CI=1.48-4.83). In the subgroup analysis by population-based controls or hospital-based controls, no statistically significantly increased risks were found. Despite some limitations, this meta-analysis suggests that the miR-146a G allele is a low-penetrant risk factor for papillary thyroid carcinoma development.
机译：关于microRNA-146a（miR-146a）G / C多态性与癌症易感性之间关联的公开数据尚无定论。为了获得更精确的关系估计，进行了荟萃分析。荟萃分析共使用23项研究，包括10585例和12183例对照。总体而言，当所有研究汇总进行荟萃分析时，未发现miR-146a G / C多态性与癌症风险之间有显着相关性（GC vs. CC：OR = 1.08，95％CI = 0.94-1.24; GG vs. CC： OR = 1.13，95％CI = 0.93-1.37;优势模型：OR = 1.09，95％CI = 0.94-1.26）。在按种族进行的亚组分析中，仍然没有发现显着的关联。在按癌症类型进行的亚组分析中，发现乳头状甲状腺癌的风险在统计学上显着增加（GC vs. CC：OR = 3.44，95％CI = 1.86-6.34; GG vs. CC：OR = 2.20，95％CI = 1.22 -3.99;优势模型：OR = 2.68，95％CI = 1.48-4.83）。在基于人群的对照或基于医院的对照的亚组分析中，未发现统计学上显着增加的风险。尽管有一些限制，但这项荟萃分析表明，miR-146a G等位基因是甲状腺乳头状癌发展的低渗透危险因素。

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