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首页> 外文期刊>Cytokine >Analysis of soluble interleukin 6 receptor in cerebrospinal fluid in inflammatory and non-inflammatory conditions.
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Analysis of soluble interleukin 6 receptor in cerebrospinal fluid in inflammatory and non-inflammatory conditions.

机译：在炎性和非炎性条件下脑脊液中可溶性白介素6受体的分析。

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The objective of this study was to investigate the pathophysiological roles of soluble interleukin 6 receptor (sIL-6R) in cerebrospinal fluid (CSF). CSF was obtained from patients suspected with meningitis. Eight patients without any meningeal signs or symptoms were enrolled as controls. An additional 34 CSF samples were collected to measure both biologically active and immunoreactive sIL-6R. All CSF samples were proven to be aseptic. IL-6 and sIL-6R were measured using specific ELISAs. Patients were divided into three groups on the basis of cell number in CSF; inflammatory group (cell number >5 microl, mean 241+/-363.1, n=61); non-inflammatory group (cell number < or =5 microl, mean=2.1+/-1.7, n=12) and controls (cell number < or =5 microl, mean=0.3+1.7, n=8). Among these three groups, the differences in protein (F (2,78)=8.274, P<0.0001) and IL-6 concentration (F (2,78)=6.475, P<0.001) were statistically significant but those of sIL-6R concentration were not. There were only weak correlations between log (sIL-6R) versus log (cell number) (r=0.23, P=0.0375), log (protein) (r=0.239, P=0.0358) and log (IL-6) (r=0.27, P=0.0167). Amounts of immunoreactive and biologically active sIL-6R were closely correlated (r=0.62, n=34, P<0.005). It was concluded that sIL-6R is present constitutively in CSF and its level may not increase significantly in inflammatory conditions; infiltrating cells in CSF are not the main source of sIL-6R; and sIL-6R in CSF can bind IL-6. Copyright 2000 Academic Press.
机译：这项研究的目的是调查脑脊髓液（CSF）中可溶性白介素6受体（sIL-6R）的病理生理作用。脑脊液来自怀疑患有脑膜炎的患者。将八名无任何脑膜体征或症状的患者作为对照。收集了另外的34个CSF样品，以测量具有生物学活性和免疫反应性的sIL-6R。所有CSF样品均被证明是无菌的。使用特异性ELISA测量IL-6和sIL-6R。根据脑脊液中的细胞数将患者分为三组。炎症组（细胞数> 5微升，平均241 +/- 363.1，n = 61）;非炎性组（细胞数≤5微升，平均值= 2.1 +/- 1.7，n = 12）和对照组（细胞数≤5微升，平均值= 0.3 + 1.7，n = 8）。在这三组中，蛋白质（F（2,78）= 8.274，P <0.0001）和IL-6浓度（F（2,78）= 6.475，P <0.001）的差异具有统计学意义，但sIL- 6R浓度没有。 log（sIL-6R）与log（细胞数）（r = 0.23，P = 0.0375），log（蛋白质）（r = 0.239，P = 0.0358）和log（IL-6）（r之间只有很弱的相关性= 0.27，P = 0.0167）。免疫反应性和生物学活性的sIL-6R含量密切相关（r = 0.62，n = 34，P <0.005）。结论是，sIL-6R组成性地存在于CSF中，在炎症条件下其水平可能不会显着升高。 CSF中的浸润细胞不是sIL-6R的主要来源。 CSF中的sIL-6R可以结合IL-6。版权所有2000学术出版社。

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