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Elevated plasma TGF-beta1 in renal diseases: cause or consequence?

机译：肾脏疾病中血浆TGF-β1升高：原因还是后果？

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We previously reported elevated levels of TGF-beta1 in patients with renal carcinoma. Certain aspects led us to ask whether they might be caused by chronic damage to the kidney(s). Here we report on an extended set of patients with various renal diseases, lung cancer, humoral immunodeficiency and controls. For latent TGF-beta1 in plasma, we find that the control, immunodeficiency, lung cancer and kidney transplant groups do not differ significantly (means, 7.0-8.8 ng/ml). Also, acute short-term renal stress (extracorporal lithotrypsy) does not lead to an increase of TGF-beta1. However, the pyelonephritis patients present with levels of 19.0 ng/ml, chronic extracorporal dialysis patients with 15.5 ng/ml, and renal cell carcinoma patients with 22.8 ng/ml. For active TGF-beta1 these findings are exactly recovered. For serum levels, only the renal carcinoma group presents with significantly elevated levels of TGF-beta1. Kidney transplantation seems to normalize TGF-beta1 levels, while in the kidney cancer patients surgery has an effect only in part of the group. We conclude that elevated plasma TGF-beta1 levels are common in at least two chronic renal disease conditions, and that it normalizes with restoration of renal function. It is tempting to speculate that chronic elevation of TGF-beta1 in these patients may be critically involved in these conditions predisposing to renal cancer. Copyright 2000 Academic Press.
机译：我们先前曾报道肾癌患者的TGF-β1水平升高。某些方面使我们问起它们是否可能由肾脏的慢性损伤引起。在这里，我们报告了一组患有各种肾脏疾病，肺癌，体液免疫缺陷和对照的患者。对于血浆中潜在的TGF-beta1，我们发现对照组，免疫缺陷组，肺癌和肾移植组没有显着差异（平均值为7.0-8.8 ng / ml）。此外，急性短期肾应激（体外碎石术）不会导致TGF-beta1的增加。但是，肾盂肾炎患者的水平为19.0 ng / ml，慢性体外透析患者的水平为15.5 ng / ml，肾细胞癌患者的水平为22.8 ng / ml。对于活性TGF-beta1，这些发现已得到准确恢复。对于血清水平，只有肾癌组的TGF-β1水平显着升高。肾脏移植似乎可以使TGF-β1水平正常化，而在肾癌患者中，手术仅对部分患者有效。我们得出的结论是，血浆TGF-β1水平升高至少在两种慢性肾脏疾病中很常见，并且随着肾功能的恢复而正常化。试图推测这些患者中TGF-β1的慢性升高可能与这些易患肾癌的疾病密切相关。版权所有2000学术出版社。

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