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首页> 外文期刊>Cytokine >The complete cDNA sequences of IL-2, IL-4, IL-6 AND IL-10 from the European rabbit (Oryctolagus cuniculus).
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The complete cDNA sequences of IL-2, IL-4, IL-6 AND IL-10 from the European rabbit (Oryctolagus cuniculus).

机译：来自欧洲兔子（穴兔（Oryctolagus cuniculus））的IL-2，IL-4，IL-6和IL-10的完整cDNA序列。

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摘要

The cDNAs for four rabbit cytokine genes [interleukin 2 (IL-2), IL-4, IL-6 and IL-10] have been cloned from primary lymphocytes by polymerase chain reaction (PCR) methods. IL-2 and IL-10 are both highly conserved between rabbit and other species. IL-4 and IL-6 are less strongly conserved, at both nucleotide and amino acid levels, and exhibit structural differences. An extension of the coding region of rabbit IL-6 relative to all other reported IL-6 genes results from a mutation in the usual stop codon which allows translation to continue for a further 27 amino acids. Analysis of IL-6 from four other lagomorph species suggests that this mutation is specific to the European rabbit. Sequence and structural differences of IL-4 and IL-6, while presumably not altering function, may render them highly species-specific. Several alternatively spliced variants of IL-2 and IL-4 are also reported. Copyright 2000 Academic Press.
机译：通过聚合酶链反应（PCR）方法从原代淋巴细胞中克隆了四种兔细胞因子基因[白介素2（IL-2），IL-4，IL-6和IL-10]的cDNA。 IL-2和IL-10在兔和其他物种之间均高度保守。 IL-4和IL-6在核苷酸和氨基酸水平上的保守性都较低，并且显示出结构差异。相对于所有其他报道的IL-6基因，兔IL-6编码区的延伸是由于通常的终止密码子发生了突变，该突变允许翻译继续进行另外的27个氨基酸。对来自其他四种兔形目物种的IL-6的分析表明，该突变是欧洲兔特有的。 IL-4和IL-6的序列和结构差异虽然可能不会改变功能，但可能使其具有高度的物种特异性。还报道了IL-2和IL-4的几种选择性剪接的变体。版权所有2000学术出版社。

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