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首页> 外文期刊>Cytokine >Tear cytokines and chemokines in patients with Demodex blepharitis.
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Tear cytokines and chemokines in patients with Demodex blepharitis.

机译：Demodex睑缘炎患者的泪液细胞因子和趋化因子。

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摘要

PURPOSE: The purpose of the study is to evaluate the causes of inflammation in Demodex-induced blepharitis by analyzing cytokine levels in lacrimal fluid. METHODS: Fifteen Demodex blepharitis patients were selected for assessment of tear cytokine concentrations. Fifteen Demodex-free blepharitis patients and 15 subjects with no ocular symptoms were selected as control groups. Minimally stimulated tear samples (20mul) were collected from each eye and analyzed using a Luminex(R) 200 Total System for detection of IL-1beta, IL-5, IL-7, IL-12, IL-13, IL-17, granulocyte colony-stimulating factor (G-CSF), and macrophage inflammatory protein-1 beta (MIP-1beta). RESULTS: The concentration of IL-17 in tears was significantly higher in the Demodex blepharitis group than in the Demodex-free blepharitis group. Tear IL-7 and IL-12 levels show serial increases for these three groups (p<0.05). There were no significant differences in the other cytokines levels between both blepharitis groups. We confirmed that elevated cytokines normalized after treatments. CONCLUSIONS: Infestation of Demodex mites induces change of tear cytokine levels, IL-17 especially, which cause inflammation of the lid margin and ocular surface. These findings might increase our understanding of the mechanism of ocular discomfort and telangiectasias frequently found in Demodex blepharitis patients.
机译：目的：本研究的目的是通过分析泪液中的细胞因子水平来评估蠕形眼炎引起的眼睑炎的炎症原因。方法：选择15例蠕形变性眼睑炎患者评估泪液细胞因子浓度。选择15例无Demodex的眼睑炎患者和15例无眼部症状的受试者作为对照组。从每只眼中收集最少刺激的眼泪样品（20 mul），并使用Luminex 200 Total System进行分析，以检测IL-1beta，IL-5，IL-7，IL-12，IL-13，IL-17，粒细胞集落刺激因子（G-CSF）和巨噬细胞炎性蛋白1 beta（MIP-1beta）。结果：Demodex睑缘炎组眼泪中的IL-17浓度显着高于无Demodex睑缘炎组。泪液IL-7和IL-12的水平显示这三组的连续性升高（p <0.05）。两个睑缘炎组之间其他细胞因子水平无显着差异。我们证实治疗后细胞因子升高正常化。结论：蠕形螨的侵染可引起眼泪细胞因子水平的变化，尤其是IL-17，这会引起眼睑边缘和眼表发炎。这些发现可能会加深我们对蠕形眼睑炎患者经常发现的眼部不适和毛细血管扩张的机制的了解。

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