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首页> 外文期刊>BJU international >Urinary nerve growth factor level is increased in patients with interstitial cystitis/bladder pain syndrome and decreased in responders to treatment.
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Urinary nerve growth factor level is increased in patients with interstitial cystitis/bladder pain syndrome and decreased in responders to treatment.

机译：间质膀胱炎/膀胱疼痛综合征患者患有尿道神经生长因子水平，并在响应者治疗中减少。

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OBJECTIVE: To measure urinary nerve growth factor (NGF) levels in patients with interstitial cystitis/bladder pain syndrome (IC/BPS), and to evaluate the role of urinary NGF in predicting the response to treatment, as the clinical diagnosis of IC/BPS is based on subjective symptoms and recent investigations suggest that urinary NGF is increased in patients with IC/BPS. PATIENTS, SUBJECTS AND METHODS: Urine samples from 122 patients with IC/BPS and 28 normal controls were measured for NGF levels using an enzyme-linked immunosorbent assay. The diagnosis of IC/BPS was based on bladder pain symptoms and the results of cystoscopic hydrodistension. Patients' perception of pain was assessed by a visual analogue scale (VAS) and a 'global' response assessment after treatment. Urinary NGF levels were further normalized to the concentration of urinary creatinine (NGF/Cr) and compared between control and IC/BPS subgroups at diagnosis and after treatment. RESULTS: Urinary NGF/Cr levels were very low when the bladder was not distended and significantly elevated with a full bladder in patients with IC/BPS. However, urinary NGF/Cr levels were not correlated with VAS scores or cystometric bladder capacity at diagnosis, or maximum bladder capacity during hydrodistension. Patients who responded to treatment and had an improvement in VAS pain score of > or =2 had significantly lower NGF/Cr levels than nonresponders who had a VAS improvement of <2. CONCLUSIONS: Patients with IC/BPS had greater urinary NGF/Cr levels than controls. A decrease of urinary NGF level was associated with greater pain reduction and a successful response, suggesting that urinary NGF levels can be a useful biomarker for detecting the severity of the bladder condition in patients with IC/BPS.
机译：目的：测量间质膀胱炎/膀胱炎/膀胱疼痛综合征（IC / BPS）患者的泌尿神经生长因子（NGF）水平，并评估泌尿NGF在预测对治疗响应中的作用，作为IC / BPS的临床诊断基于主观症状，最近的研究表明，IC / BPS患者尿NGF增加。患者，受试者和方法：使用酶联免疫吸附试验测量来自IC / BPS和28例正常对照的122名患者的尿液样本。 IC / BPS的诊断基于膀胱疼痛症状和膀胱镜散热物的结果。通过视觉模拟量表（VAS）和治疗后的“全球”反应评估评估患者的疼痛感。尿道NGF水平进一步归一化为尿肌酐（NGF / CR）的浓度，并在诊断和治疗后进行对照和IC / BPS亚组进行比较。结果：当膀胱在IC / BPS患者中，膀胱没有扩散并显着升高时，NGF / Cr水平非常低。然而，尿道NGF / Cr水平与VAS分数或膀胱膀胱膀胱容量无关，或在氢化机期间的最大膀胱容量。应对治疗和改善VAS疼痛评分>或= 2的患者显着降低NGF / CR水平，而不是患有VAS改善<2的无关。结论：IC / BPS患者具有比对照更大的NGF / Cr水平。泌尿NGF水平的降低与更高的疼痛减少和成功的反应相关，表明尿道NGF水平可以是用于检测IC / BPS患者膀胱病症的严重程度的有用生物标志物。

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